Inflammation Drugs Uses and Side effects Flashcards
Acetylsalicylic Acid (ASA, aspirin)
Use: Antiplatelet, analgesic and antipyretic, antiinflammatory (at high doses); often taken as baby aspirin to preven MI and CVA
SE: GI irritation, bleeding and anemia, hepatoxicity, and salicylate toxicity. Nephrotoxicity in elderly or hypovolemic pt
Diflunisal
Use: Osteoarthritis, MSK strains/sprains, pain after dental extraction, postepisiotomy pain. Better than aspirin for inflammatory conditions
SE: Fewer GI side effects and less platelet effects than aspirin.
Acetaminophen (tylenol)
Use: Analgesic and antipyretic effect similar to aspirin but weak anti inflammatory effects
SE: renal tubular necrosis if chronically abused; hepatic necrosis with overdose. Less GI irritation than aspirin
Indomethacin
Use: rheumatoid arthritis (10x as potent as aspirin), ankylosing spondylitis, osteoarthritis, acute gout
SE: At times, thrombocytopenia, aplastic anemia, severe frontal headaches, nephrotoxicity in elderly and hypovolemic. Toxicities cause 25% of pt to stop
Sulindac
Use: Rheumatoid arthritis (half as potent as indomethacin) ankylosing spondylitis, osteoarthritis, acute gout
SE: At times, thrombocytopenia, aplastic anemia, severe frontal headaches, nephrotoxicity in elderly and hypovolemic.
Ibuprofen
Use: Rheumatic disorders, osteoarthritis, ankylosing spondylitis, postpartum pain, dysmenorrheal pain, and many types of surgeries
SE: GI irritation; hepatotoxicity (less frequent than aspirin)
Flurbiprofen
Use: Rheumatic disorders, osteoarthritis, ankylosing spondylitis, postpartum pain, dysmenorrheal pain, and many types of surgeries, obtains high synovial concentration
SE: GI irritation; hepatotoxicity (less frequent than aspirin)
Naproxen
Use: Rheumatic disorders, osteoarthritis, ankylosing spondylitis, postpartum pain, dysmenorrheal pain, and many types of surgeries
SE: GI irritation; hepatotoxicity (less frequent than aspirin)
Longer T1/2 13 hrs
Oxaprozin
Use: Rheumatic disorders, osteoarthritis, ankylosing spondylitis, postpartum pain, dysmenorrheal pain, and many types of surgeries
SE: GI irritation; hepatotoxicity (less frequent than aspirin)
Very long T1/2 50 hrs
Piroxicam
Use: Long term treatment of rheumatoid arthritis or osteoarthritis; also, ankylosing spondylitis, acute MSK disorders and gout
SE: same as aspirin
Very long T1/2 45 hrs permits once daily dosing
Ketorolac
Use: Post operative pain; inflammatory eye conditions
SE: same as aspirin
Injectable equally or more efficacious than morphine T1/2 4-6hrs
Celocoxib
Use: same as other NSAIDs
SE: less GI toxicity
Contraindicated in patients with heart problems or pregnancy
Etoricoxib
Use: same as other NSAIDs
SE: less GI toxicity
Contraindicated in patients with heart problems or pregnancy
