Malaria Drugs class and mechanism

Question 1

Quinine

Answer 1

Quinolone derivative
Accumulate in parasites food vacuole, disrupt heme polymerization to hemozoin, yielding oxidative damage to membranes and digestive processes

Question 2

Chloroquine

Answer 2

Quinolone derivative
Accumulate in parasites food vacuole, disrupt heme polymerization to hemozoin, yielding oxidative damage to membranes and digestive processes

Question 3

Hydroxychloroquine

Answer 3

Quinolone derivative
Accumulate in parasites food vacuole, disrupt heme polymerization to hemozoin, yielding oxidative damage to membranes and digestive processes

Question 4

mefloquine

Answer 4

Quinolone derivative
Accumulate in parasites food vacuole, disrupt heme polymerization to hemozoin, yielding oxidative damage to membranes and digestive processes

Question 5

Primaquine

Answer 5

Quinolone derivative

Attacks in liver cell, forms quinolone-quinone intermediates that oxidize schizont membranes

Question 6

Amantadine

Answer 6

Positive charge helps chloroquine overcome chloroquine resistant malaria vacuoles; point mutations against amantadine return bacteria to cholorquine sensitivity

Question 7

Artesunate

Answer 7

Artemisinin compound

Specifically and selectively inhibits SERCA of p. falciparum

Question 8

Artemether

Answer 8

Artemisinin compound

Specifically and selectively inhibits SERCA of p. falciparum

Question 9

Lumefantine

Answer 9

aminoalcohol

Question 10

Atovaquone

Answer 10

Napthalene

depolarizes parasitic mitochondria and inhibits their electron transport

Question 11

Chloroguanide (Proguanil)

Answer 11

Antifolates

Dihydrofolate reductase inhibitors (Human and parasite pathway)

Question 12

Tetracycline

Answer 12

Antibiotic

Question 13

Clindamycin

Answer 13

Antibiotic

Question 14

Doxycycline

Answer 14

Antibiotic