Cholinomimetics (class/mechanism)

Question 1

Bethanecol (urecholine)

Answer 1

Direct acting carbamic acid ester

Direct acting muscarinic cholinomimetic

Question 2

Muscarine

Answer 2

Direct acting nonester alkaloid

DIrect acting muscarinic cholinomimetic

Question 3

Pilocarpine (Salagen)

Answer 3

Direct acting nonester alkaloid

Direct acting muscarinic cholinomimetic (can be absorbed through the skin)

Question 4

Cevimeline (Evoxac)

Answer 4

Direct acting nonester alkaloid

Direct acting muscarinic cholinomimetic (relatively specific for M3)

Question 5

Nicotine (NRT)

Answer 5

Direct acting nonester alkaloid

direct acting nicotinic cholinomimetic

Question 6

Neostigmine (prostigmin)

Answer 6

Indirect acting carbamate
AChE inhibitor (short acting)

Question 7

Physostigmine (Eserine)

Answer 7

Indirect acting carbamate
AChE inhibitor (Short acting)

Question 8

Donepezil (Aricept)

Answer 8

Indirect acting non-ester
AChE inhibitor (readily crosses BBB)

Question 9

Edrophonium (Enlon)

Answer 9

indirect acting non-ester AChE inhibitor (v. Short acting)

Question 10

Echothiophate (Phospholine)

Answer 10

indirect acting organophosphate
AChE inhibitor (long acting)

Question 11

Pralidoxime (Protopam)

Answer 11

Strong nucleophile

regenerates phosphorylated AChE

Question 12

Sarin

Answer 12

Very potent indirect acting organophosphate
AChE inhibitor (Very fast aging)