THERAPEUTICS - clindamycin Flashcards
1
Q
what is the chemical name for clindamycin?
A
lincosamide
2
Q
what anaerobes does clindamycin target?
A
gram +ve/ gram -ve bacterial
anaerobic/ facultative/ aerobic
3
Q
what is clindamycins mechanism of action?
A
inhibits protein synthesis
bactericidal at high conc
4
Q
what is the half life of clindamycin?
A
3 hours
5
Q
where is clindamycin metabolised?
A
liver 90%
bile
6
Q
how is clindamycin excreted?
A
urine
7
Q
what are unwanted effects of clindamycin?
A
nausea/ vomiting
abdominal pain
glossitis
allergy
metallic taste
potentially fatal
8
Q
what are clindamycins interactions?
A
non-depolarising neuromuscular blocking agents
absorption slowed by some anti-diarrhoeal drugs
antagonism with erythromycin
9
Q
what is the dose of clindamycin?
A
150-300mg
6 hourly
3-5 days
