THERAPEUTICS - aspirin NSAIDS Flashcards
What is the chemical name for aspirin?
acetylsalicylic acid
list the 4 features of aspirin?
anti-pyrexic
anti-platelet/ thrombotic
anti-inflammatory
analgesic-mild/ moderate
what does anti-pyrexic mean?
something that reduces fever
how does aspirin present and what is it’s route?
white tablet
dispersible when swallowed
what happens if someone sits an aspirin tablet in their mucosa?
can cause sloughing
what is aspirins mechanism of action?
COX isoenzyme inhibition
COX inhibition reduces eicosanoid (prostanoid) synthesis
aspirin = irreversible inhibition by acetylation
what are prostaglandin (PGE2) prostacycline (PGI2) and thromboxane (TXA)?
products of arachidonic acid which play a role in the regulation of haemostatic plug and thrombus formation
what actions do PGE2 and TXA hold?
regulate BP
renal effects
inflammatory response
duration and intensity of pain
fever
gastric effects (elevate acid)
inhibits platelet aggregation and thrombosis
what effect does aspirin have on COX activity?
COX-1 > COX-2
Anti-inflammatory (COX2)
adverse effects (COX1) - inhibition
=inflammatory control
what are indications for the use of aspirin?
acute pain
dental pain
rheumatic fever
rheumatoid arthritis (increases mobility)
fever
acute coronary syndrome/ ischaemic stroke
anti-thrombotic
where is aspirin absorbed?
rapidly absorbed GI, stomach and small intestine
what is aspirins half life?
20-30 mins
does aspirin cross the placenta?
yes and is evident in breast milk also
what are contraindications and side effects of aspirin?
GI issues
Resp issues (AERD)
Increases renal failure
Gout (increases uric acid)
Can cause tinnitus
Glycaemic control
Pregnancy
what is Reye’s syndrome?
swelling in liver and brain - can be made worse with aspirin
avoid aspirin in children secondary to reyes syndrome
