The pathology of aging Flashcards
1
Q
give some exmaples of What can increase wear on cells
A
- Cross linking/Mutations od DNA
- Telomere shortening
- Time dependant activation ageing and death genes
- Accumulation of toxic by products of metabolism
- Free radical generation
- Damage to mitochondria DNA
- Loss of DNA repair mechanise
- Peroxidation
2
Q
what causes wrinkled skin
A
- DNA cross lining
- caused by exposure to UVB light
3
Q
Why does chromic inflam cause cancer
A
- cellular changes and immune responses to repair damaged tissues —> cell proliferate at site of injury
- Inflam response become chronic increasing cell prolif and increasing risk of mutation
- Chromic inflam cells (macrophages) generate high levels of reatctive N and O species to fight infection and releasing mutoagenic agents
- Inflam cells also release factors that interfere with regular of replication exacerbating tumourgenesis
4
Q
A
