Immunology Flashcards
what are the 2 main cells that come from a pluripotenent haeopoetic stem cell
myeloid cell and lymphoid cell
what 4 cells can a myeloid cell differentiate to
Megakaryocyte
Eerythrocyte (also reticulocyte)
Mast cell
Myeloblast
what cells can a myeloid cell differentiate into and why is this group of cells so important
Eosinophil
Neutrophil
Basophil
Macrophge (from monocyte)
-They for the cells of innate immunity
what cells can the common lymphoid progenitor differentiate into
Lymppcyte
natural T Killer cell
what does a lymphocyte differentiate into
T cell
Bcell (then plasma cell)
what cells from the common lymphoid progenitor cell form adaptive (aka specific + acquired) immune system
- Natral T killer cell
- T cell
- B cell
- Plasma cell
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what are the primary lympoid organs
- Bone marrow - origin of all immune cells, B cell maturation site
- Thymus - T cell maturation site, thymic tolerance
what are the secondary lymphoid organs
- lymph nodes - Site of DC, B and T cell interactions
- spleen - RBC recycle
What are the tertiary lymphoid organs
- Germinal centres of rapidly proliferating lymphocytes
descrobe the characteristics of innate immunitys
- non specific
- quick
- no memory
- physical barriers - skin, mucus
- Chemical barriers- stimach acid, tears
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specific functions igM antibodies
IgM; produced early in immune response, opsonisation, agglutination and complement activation
specific functions of IgA
IgA; mucosal immunity (gut and lung)
specific function of IgG
IgG; most abundant, highly specific, cytotoxicity, neutralises toxins, opsonisation and complement activation
specific functions of IgD
IgD; found on surface of B cells, development of immune response
specific functions of IgE
IgE; attached to mast cells, mediates allergic reactions
