Pharmacology of non-insulin treatment options in diabetes for type 2 diabetes Flashcards
1
Q
what are the pillars are diabetes management
A
- glycermic control
- blood pressure emanaglent
- lipid managent
- agesnt with cardiovaular and kidnery benerfir
2
Q
what drugs are used to treat the insulin resistance
A
metformin (first line)
pioglitazon
3
Q
what drugs ot use to stimulate pancreas to release insulin
A
sulphonyureas
DPP-4 inhibitors
GLP-1 receptor agonists
4
Q
what are incretins
A
- hormones secrete by intertinal endocrine cells in response to nutritional intake
- incretins influence glucose homeostasis via: glucose dependant insulin secretion, postprandial glucagon suppression, and slowing of gastric emptying
5
Q
what is GLP-1
A
6
Q
What do DPP-4 inhibitors do
A
inhibits breakdown of GLP-1
7
Q
DPP-4 Inhibitors are competitive antagonists
T/F
A
T
8
Q
What do GLP-1 analogues do
A
- Large increase in GLP-1 level
- delays gastric emptying
- Likely to induce nausea/ vomiting
- Induces weight loss
- Effects are mediated by GLP-1 Receptor
- Injectable
9
Q
A
