Tetracyclines

Question 1

Examples:

Answer 1

1. Doxycycline
2. Tigecycline

Question 2

MOA:

Answer 2

1. Bind to the bacterial ribosome
2. Interfering with protein synthesis

Question 3

Spectrum:

Answer 3

1. Chlamydia / Chlamydophila
2. Intracellular bacteria- Legionella
3. Mycoplasma
4. Rickettsiae
5. Highly resistant gram-negative bacilli - including Acinetobacter baumannii — tigecycline

Question 4

S/E:

Answer 4

1. Permanent tooth discoloration in children
2. Photosensitivity
3. Hepatotoxicity in pregnant women

Question 5

Contraindications:

Answer 5

1. Children
2. Pregnant women

Question 6

Indications:

Answer 6

1. Rickettsial disease - Rocky Mountain spotted fever [RMSF] & ehrlichiosis
2. Complicated skin and soft tissue infections - including MRSA - tigecycline
3. Complicated intraabdominal infections - tigecycline
4. VAP - tigecycline