Clindamycin

Question 1

MOA:

Answer 1

1. Interferes with bacterial protein synthesis

Question 2

Spectrum:

Answer 2

1. MRSA
2. Aerobic gram-positive organisms
3. Anaerobic bacteria - gram-positive & gram negative but NOT some clostridia
4. Protozoa - Toxoplasma gondii

Question 3

Indications:

Answer 3

1. Complicated and mixed intra-abdominal infections
2. Community-acquired MRSA infections
3. Brain abscess in AIDS patients (in combination with pyrimethamine)
4. PJP in AIDS patients

Question 4

S/E:

Answer 4

1. Diarrhea - C.diificile colitis
2. Mild reversible increase in liver enzymes