Colistin

Question 1

MOA:

Answer 1

1. Disrupts the outer membrane of gram-negative organisms
2. Osmotically unstable
3. Killing them

Question 2

Spectrum:

KEPA

Answer 2

1. Multidrug-resistant gram-negative rods - Klebsiella, E. coli, Pseudomonas, Acinetobacter

Question 3

Indications:

Answer 3

1. Last resort for treating infections
2. Caused by multidrug-resistant gram-negative rods
3. Esp. in critically ill patients or those with decreased immunity

Question 4

S/E:

Answer 4

1. Nephrotoxicity (30–60% risk)
2. Reversible neurotoxicity