Daptomycin

Question 1

MOA:

Answer 1

1. Build up in the cell membranes of susceptible gram-positive organisms
2. Membranes become porous (leaky)
3. Osmotically unstable
4. Cell death

Question 2

Spectrum:

Answer 2

1. Multidrug-resistant gram-positive organisms

Question 3

Indications:

Answer 3

1. Staphylococcal bacteremia - especially MRSA
2. Right-sided IE
3. Complicated skin and soft tissue infections
4. Should NOT be used for pneumonia - inactivated by lung surfactant

Question 4

S/E:

Answer 4

1. Skeletal muscle toxicity
2. Immune thrombocytopenia