Echinocandins

Question 1

MOA:

Answer 1

1. Binds to cell membrane of fungi
2. Interferes with function of specific enzymes
3. Causes cell wall to become osmotically unstable

Question 2

Spectrum:

Answer 2

1. Fungi

Question 3

Indications:

Answer 3

1. Candida oesophagitis
2. Disseminated candidiasis - first line Rx for invasive candida infections - except CNS & UTIs
3. Candidaemia
4. Invasive aspergillus infections - NOT first line
5. Intra-abdominal abscesses
6. Peritonitis
7. Pleural space infections

Question 4

S/E:

Answer 4

1. Pruritus at IV site
2. Headache
3. Fever
4. Chills
5. GI upset