Beta-lactamase Inhibitors

Question 1

Examples:

Answer 1

1. Amoxicillin-clavulanate
2. Ampicillin-sulbactam
3. Piperacillin-tazobactam

Question 2

Spectrum:

Answer 2

1. Same coverage as penicillins but broadened
2. Anaerobic bacteria
3. Enteric organisms - some resistant E. coli
4. MRSA
5. Pseudomonas aeruginosa - piperacillin-tazobactam only

Question 3

Indications:

Answer 3

1. Many hospital-acquired infections
2. VAP - piperacillin-tazobactam
3. Mixed infections - wound and intra-abdominal infections

Question 4

S/E:

Answer 4

1. IgE-mediated anaphylaxis
2. Morbilliform rash
3. Diarrhea