Beta-lactamase Inhibitors Flashcards

1
Q

Examples:

A
  1. Amoxicillin-clavulanate
  2. Ampicillin-sulbactam
  3. Piperacillin-tazobactam
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2
Q

Spectrum:

A
  1. Same coverage as penicillins but broadened
  2. Anaerobic bacteria
  3. Enteric organisms - some resistant E. coli
  4. MRSA
  5. Pseudomonas aeruginosa - piperacillin-tazobactam only
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3
Q

Indications:

A
  1. Many hospital-acquired infections
  2. VAP - piperacillin-tazobactam
  3. Mixed infections - wound and intra-abdominal infections
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4
Q

S/E:

A
  1. IgE-mediated anaphylaxis
  2. Morbilliform rash
  3. Diarrhea
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