Beta-lactamase Inhibitors Flashcards
1
Q
Examples:
A
- Amoxicillin-clavulanate
- Ampicillin-sulbactam
- Piperacillin-tazobactam
2
Q
Spectrum:
A
- Same coverage as penicillins but broadened
- Anaerobic bacteria
- Enteric organisms - some resistant E. coli
- MRSA
- Pseudomonas aeruginosa - piperacillin-tazobactam only
3
Q
Indications:
A
- Many hospital-acquired infections
- VAP - piperacillin-tazobactam
- Mixed infections - wound and intra-abdominal infections
4
Q
S/E:
A
- IgE-mediated anaphylaxis
- Morbilliform rash
- Diarrhea