Azoles

Question 1

Examples:

Answer 1

1. Fluconazole
2. Voriconazole
3. Itraconazole
4. Posaconazole

Question 2

MOA:

Answer 2

1. Interfere with fungal cell membrane
2. Interfere with ergosterol synthesis

Question 3

Spectrum:

Answer 3

1. Fungi
2. Mild illness - oral form
3. Severe illness - IV form

Question 4

Indications:

Answer 4

1. Endemic fungi - itraconazole
2. Coccidioides meningitis - fluconazole
3. Aspergillus

Question 5

S/E:

Answer 5

1. Drug-drug interactions - Block CYP450 - Warfarin - bleeding tendencies
2. Photosensitivity
3. Visual hallucinations - voriconazole

Question 6

Stewardship concerns:

Answer 6

1. Emergence of multi-drug resistant candida infections