Nitroimidazoles

Question 1

Examples:

Answer 1

1. Metronidazole
2. Tinidazole

Question 2

MOA:

Answer 2

1. Disrupts the electron transport system of anaerobic bacteria
2. Depriving the organism of ATP
3. Resulting in a metabolic product that damages anaerobe DNA

Question 3

Spectrum:

Answer 3

1. Most anaerobic organisms

Question 4

Indications:

Answer 4

1. Intra-abdominal infections
2. C. dificile colitis
3. Gynecological infections
4. Anaerobic protozoal infections

Question 5

S/E:

Answer 5

1. Seizures
2. Peripheral neuropathy (with prolonged use)