Flucytosine

Question 1

MOA:

Answer 1

1. Possess 2 enzymes
2. 1 - allows entry into cell
3. 2 - converts drug to 5-Fluorouracil
4. Acts on fungal nucleic acids - As a chain terminator
5. Killing the organism

Question 2

Spectrum:

Answer 2

Fungi

Question 3

Indications:

Answer 3

1. 1st phase of Rx for CCM
2. Invasive candidiasis
3. Candida UTI - concentrated in urine

Question 4

Adverse reactions:

Answer 4

1. Bone marrow suppression
2. Diarrhoea
3. Intestinal perforation

Question 5

Stewardship:

Answer 5

1. Close monitoring of bone marrow function
2. Close monitoring of diarrhoea