Test 4 drugs Flashcards by John Goodman

Q

Albuterol

Class? Mechanism? Clinical uses?

A

Beta agonsit (short acting)

β2-adrenergic receptor agonist

asthma, COPD

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Q

Albuterol toxicity?

A

Tremor, tachycardia

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Q

Salmeterol

Class? Mechanism? Clinical uses?

A

Beta agonist (Long acting)

β2-adrenergic receptor agonist

asthma, COPD

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Q

Salmeterol toxicity?

A

cough, runny nose, sneezing, headache

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Q

Formoterol

Class? Mechanism? Clinical uses?

A

Beta agonists (Long acting)

β2-adrenergic receptor agonist

asthma (severe), exercise induced bronchospasm, COPD

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Q

Formoterol toxicity

A

cough, runny nose, sneezing, headache

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Q

Theophylline

Class? Mechanism? Clinical uses?

A

Methylxanthines

PDE3 inhibitor, adenosine receptor antagonist

acute asthma relief, controller medication

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Q

Theophylline toxicity?

A

insomnia, tremor, anorexia

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Q

Ipratropium

Class? Mechanism? Clinical uses?

A

Muscarinic antagonists

M3 musc antagonist

COPD, asthma, rhinitis

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Q

Ipratropium toxicity?

A

dry mouth, cough

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Q

Fluticasone

Class? Mechanism? Clinical uses?

A

Inhaled Corticosteroids

glucocorticoid receptor agonist

asthma controller medication, anti-allergenic

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Q

Fluticasone toxicity?

A

cough, headache, nausea

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Q

Prednisone

Class? Mechanism? Clinical uses?

A

Systemic Corticosteroids

glucocorticoid receptor agonist

asthma controller medication, anti-allergenic

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Q

Prednisone toxicity?

A

cough, headache, nausea

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Q

Cromolyn

Class? Mechanism? Clinical uses?

A

Mast Cell Stabilizers

mast cell stabilizer

asthma controller medication

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Q

Cromolyn toxicty?

A

cough, nausea, throat irritation

Q

Roflumilast

Class? Mechanism? Clinical uses?

A

Phosphodiesterase inhibitors

selective phosphodiesterase type 4 inhibitor

reducing acute COPD exacerbations

Q

Roflumilast toxicity?

A

diarrhea, weight loss, nausea

Q

Montelukast

Class? Mechainsm? Clincal uses?

A

Leukotriene antagonist

Cys-LTR1 receptor antagonist

asthma, exercise induced bronchospasm, allergic rhinitis

Q

Montelukast toxicity?

A

GI disturbances, hypersensitivity reactions

Q

Azithromycin

Class? Mechanism? Clinical uses?

A

Macrolide antibiotic

inhibits 50s subunit of bacteria ribosome, inhibiting RNA translation

reducing acute COPD exacerbations

Q

Azythromycin toxicity?

A

Hearing impairment

Q

Omalizumab

Class? Mechanism? Clinical uses?

A

IgE sequestrant

binds serum IgE antibodies

asthma controller medication

Q

Omalizumab toxicity?

A

headache, dizziness, fatigue

Q

Diphenhydramine

Class? Mechanism? Clinical uses?

A

Anti-Histamine

H1-histamine receptor antagonist

allergy, insomnia, motion sickness

Q

Diphenhydramine toxicty?

A

sedation (+++), anti-cholinergic activity (+++)

Q

Hydroxyzine

Class? Mechanism? Clinical uses?

A

Anti-Histamine

H1-histamine receptor antagonist

allergy, potentiate opioid analgesia, general anxiety

Q

Hydroxyzine toxicity?

A

sedation (+++), anti-cholinergic activity (+++)

Q

Brompheniramine

Class? Mechanism? Clinical uses?

A

Anti-Histamine

H1-histamine receptor antagonist

allergy, common cold

Q

Brompheniramine toxicity?

A

sedation (+), anti-cholinergic activity (+)

Q

Promethazine

Class? Mechanism? Clinical uses?

A

Anti-Histamine

H1-histamine receptor antagonist

allergy, motion sickness

Q

Promethazine toxicity?

A

sedation (+++), anti-cholinergic activity (+++)

Q

Loratidine

Class? Mechanism? Clinical uses?

A

Anti-Histamine

H1-histamine receptor antagonist

allergy

Q

Loratidine toxicity?

A

non-sedating minimal AC activity