Test 3 Pharm

Question 1

Unfractionated Heparin

Class? mechanism of action? Clinical uses?

Answer 1

Anti-coagulant

complexes with antithrombin III

venous thrombosis, pulmonary embolism, myocardial infarction, unstable angina

Question 2

Unfractionated Heparin toxicity?

Answer 2

bleeding, thrombocytopenia, osteoperosis

Question 3

Enoxaparin

Class? mechanism of action? Clinical uses?

Answer 3

Anti-coagulant

low molecular weight heparin

venous thrombosis, pulmonary embolism, myocardial infarction, unstable angina

Question 4

Enoxaparin toxicity?

Answer 4

bleeding, thrombocytopenia, osteoperosis

Question 5

Clopidogrel

Class? mechanism of action? Clinical uses?

Answer 5

Anti-platelet

non-competitive P2Y12 receptor antagonist

venous thrombosis, prevent stent-induced restenosis, acute coronary syndrome, unstable angina

Question 6

Clopidogrel toxicity?

Answer 6

bleeding, itching

Question 7

Abciximab

Class? mechanism of action? Clinical uses?

Answer 7

Anti-platelet

Glycoprotein IIb/IIIa antagonist

acute coronary syndrome, prevent restenosis during PCI, unstable angina

Question 8

Abciximab toxicity?

Answer 8

bleeding, thrombocytopenia

Question 9

Aspirin

Class? mechanism of action? Clinical uses?

Answer 9

Anti-platelet

non-selective, irreversible cyclooxygenase inhibitor

prevention and treatment of arterial thrombosis, anti-inflammatory

Question 10

Aspirin toxicity?

Answer 10

GI- and nephro-toxic, hypersensitivity reactions

Question 11

Alteplase

Class? mechanism of action? Clinical uses?

Answer 11

Thrombolytic

converts plasminogen to plasmin

coronary artery thrombosis, pulmonary embolism, ischemic stroke

Question 12

Alteplase toxicity?

Answer 12

bleeding, cerebral hemorrhage

Question 13

Streptokinase

Class? mechanism of action? Clinical uses?

Answer 13

Thrombolytic

Directly activates plasmin, resulting in fibrin degradation.

coronary artery or deep vein thrombosis, pulmonary embolism, ischemic stroke

Question 14

Streptokinase toxicity?

Answer 14

bleeding, cerebral hemorrhage

Question 15

Metoprolol

Class? mechanism of action? Clinical uses?

Answer 15

beta blocker

β1-adrenergic receptor antagonist

congestive heart failure, hypertension, angina

Question 16

Metoprolol toxicity?

Answer 16

bradycardia, AV block, CNS sedation

Question 17

Carvedilol

Class? mechanism of action? Clinical uses?

Answer 17

beta blocker

mixed α1- and β-adrenergic receptor antagonist

congestive heart failure, hypertension, angina

Question 18

Carvedilol toxicity?

Answer 18

bradycardia, AV block, CNS sedation

Question 19

Diltiazem

Class? mechanism of action? Clinical uses?

Answer 19

Ca2+ channel blocker

cardioselective L-type Ca2+ channel blocker

angina, arrhythmias, hypertension

Question 20

Diltiazem toxicity?

Answer 20

excessive cardiac depression, constipation

Question 21

Amlodipine

Class? mechanism of action? Clinical uses?

Answer 21

Ca2+ channel blocker

vascular selective L-type Ca2+ channel blocker

angina, hypertension

Question 22

Amlodipine toxicity?

Answer 22

hypotension, flushing, dizziness

Question 23

Nitroglycerin

Class? mechanism of action? Clinical uses?

Answer 23

vasodilator

nitric oxide donor (decrease preload is major effect)

angina, acute coronary syndrome

Question 24

Nitroglycerin toxicity?

Answer 24

tachycardia, hypotension