Test 2 Pharm Flashcards
Furosemide
Class? mechanism of action? Clinical uses?
Diuretic
Inhibits Na+/K+/2Cl- cotransporter increasing [solute] which draws water into the lumen –> increased urine output
Edema, hypercalcemia, hypertension
Furosemide toxicity?
hypokalemia, ototoxicity
Lisonopril
Class? mechanism of action? Clinical uses?
RAAS drug
inhibits angiotensin converting enzyme (ACE)
CHF, hypertension, diabetic renal disease
Lisonopril toxicity?
bradykinin cough reflex, hyperkalemia, teratogenic
Valsartan
Class? mechanism of action? Clinical uses?
RAAS drug
angiotensin II receptor antagonist
CHF and hypertension
Valsartan toxicity?
hyperkalemia, teratogenic
spironolactone
Class? mechanism of action? Clinical uses?
RAAS drug
aldosterone receptor inhibitor
CHF, hypertension, hyperaldosteronism
spironolactone toxicity?
hyperkalemia, endocrine effects
Carvedilol
Class? mechanism of action? Clinical uses?
Beta blocker
B1 and alpha 1 antagonist
heart failure, hypertension
Carvedilol toxicity?
bradycardia, bronchoconstriction, AV block, CNS sedation
Metoprolol
Class? mechanism of action? Clinical uses?
Beta blocker/ class II antiarrhythmic
B1 antagonist
heart failure, hypertension, angina, arrhythmias
Metoprolol toxicity?
bradycardia, AV block, CNS sedation
Dobutamine
Class? mechanism of action? Clinical uses?
Inotrope and chronotrope
B1 agonist
heart failure
Dobutamine toxicity?
arrhythmia
digoxin
Class? mechanism of action? Clinical uses?
ionotrope/cardiac glycoside
inhibits Na+/K+ pump, which increases intracellular [Ca2+] via Na+/Ca2+ exchanger
heart failure, arrhythmias
digoxin toxicity?
visual disturbances, nausea, arrhythmias
Milrinone
Class? mechanism of action? Clinical uses?
inotrope
phosphodiesterase inhibitor which increases cAMP
heart failure
Milrinone toxicity?
arrhythmia
Hydralazine
Class? mechanism of action? Clinical uses?
Vasodilator
opens vascular K+ channels resulting in relaxation –> decreased afterload
heart failure, angina
Hydralazine toxicity?
tachycardia, hypotension, headache