TDDS

Question 1

Transdermal Drug Delivery System is also known as

Answer 1

Patch or Transdermal Patches

Question 2

Dosage form intended for delivering or passage of drug across skin to systemic absorption

Answer 2

Transdermal Drug Delivery System

Question 3

TDDS is intended for drugs with ____ and _______

Answer 3

TDDS is intended for drugs with short biological half life and first pass effect

Question 4

Two types of TDDSs

Answer 4

1. Monolithic Transdermal System
Incorporate a drug matrix layer between the backing & frontal layers

2. Membrane-controlled Transdermal System
Designed to contain a drug reservoir or pouch, usually in liquid or gel form, a rate-controlling membrane, & backing, adhesive & protecting layer

Question 5

Parts of Transdermal Drugs

Answer 5

1. Occlusive Backing Layer
2. Drug Matrix System / Drug Reservoir
3. Adhesive Layer
4. Protective Strip / Release Liner

Question 6

Prevents water loss and drug loss from matrix or reservour

Answer 6

Occlusive Backing Layer

Question 7

Store & release the drug at the skin site.

Answer 7

Drug Reservoir / Drug Matrix System

Question 8

Ensures drug contact and continued drug delivery

Answer 8

Adhesive layer

Question 9

Removed before application & enables drug release

Answer 9

Release liner / Protective Strip

Question 10

Considerations in TDDS Application

Answer 10

1. Percutaneous absorption may vary with the site of application.
2. TDDSs should be applied to clean, dry skin that is relatively free of hair and not oily, irritated, infl amed, broken, or callused.
3. Use of skin lotion should be avoided
4. TDDSs should not be physically altered by cutting.
5. A TDDS should not tear or cut into the unit.
6. A TDDS should be placed at a site that will not subject it to being rubbed off by clothing or movement
7. A TDDS should be worn for the full period
8. Cleanse the hands thoroughly before and after applying a TDDS.
9. Seek reevaluation if sensitive.
10. Upon removal, a used TDDS should be folded in half with the adhesive layer together so that it cannot be reused.

Question 11

Principle of TDDS Administration

Answer 11

The basis for the development of transdermal drug delivery systems involves percutaneous absorption.

Question 12

First approved Transdermal in 1979

Answer 12

Scopolamine

Baxter®

Question 13

Scopolamine

Answer 13

For motion Sickness
Applied behind ears

Question 14

First TDDS for Hypertension

Answer 14

Clonidine

Placed in torso/upper back

Question 15

For the relief of pain associated w/ angina pectoris

Answer 15

Nitroglycerin

Placed on chest

Question 16

For smoking cessation to prevent withdrawal symptoms & physical dependence

Answer 16

Nicotine

Placed on upper arm/torso/hips

Question 17

TDDS for hormone replacement therapy

Answer 17

Testosterone/Estradiol

Question 18

Opioid Analgesic

Answer 18

Fentanyl

Question 19

Enhances the transport of some solute molecules by creating a potential gradients through the skin w/ an applied electrical current or voltage

Answer 19

Iontophoresis

Question 20

Transport of drugs through the skin using ultrasound

Answer 20

Sonophoresis/Phonophoresis

Question 21

Application of short, high (100v) voltage electric pulses -> aqueous pores

Answer 21

Electroporation

Question 22

Uses of super sonic shockwaves (helium gas) to enhance drug diffusion through skin

Answer 22

High Velocity Powder Particles