Non-Aqueous Solutions Flashcards
Clear, sweetened flavored hydroalcoholic liquids intended oral use.
Elixirs
Ingredients of Elixirs
Ethanol
Water
Glycerin
Sorbitol
Propylene glycol
Flavoring Agents
Preservatives
Syrups
Alcohol content of Elixirs
5 - 40%
Self-preserving: >10%
Examples of Elixirs
Aromatic Elixir, NF - 22% alcohol
Combination of Low Alcoholic Elixir (8-10%) and High alcohol elixir (73 - 78%)
Iso-alcohol Elixir
Alcoholic solution or hydroalcoholic preparations of volatile substances prepared usually by simple solution or by admixture of the ingredients
Spirits/Essences
Alcohol content of Spirits
> 60%
Use of Spirits
Flavoring Agents
Preparation of Spirits
Simple Solution
Maceration
CHemical Reaction
Distillation
Method of Preparation of Aromatic Ammonia Spirit
Simple Solution
Method of Preparation of Peppermint Spirit and Spearmint Spirit
Maceration
Method of Preparation of Ethyl nitrite Spirit
Chemical Reaction
Method of Preparation of Brandy and Whiskey
Distillation
Brandy - Spiritus vini vitis
Whiskey - Spiritus frumenti
Locally applied solutions that precipitate proteins and cause constriction of the skin
Astringents
Astringent can be used as ____ as they reduce secretions
Astringent
Examples of Astringents
o Aluminum Acetate Topical Solution – wet dressing in contact dermatitis
o Calcium Hydroxide Topical Solution – more soluble in cold water
o Coal Tar Topical Solution – for eczema
Kill bacteria when applied to skin or mucous membrane in the proper strength
Local Anti-Infective Solutions
Local anti-infectives solutions
Povidone Iodine Topical soln
Thimerosal Topical Soln
Hydrogen peroxide
Used as an antiseptic and surgical scrub
Povidone iodine topical soln
Components of Povidone iodine topical soln
10% Iodine + Polyvinylpyrrolidone
Water soluble organic mercurual antibacterial agent
Thimerosal Topical soln
0.1% Thimerosal
3% Hydrogen peroxide
10 volume - Wound antiseptic
6% Hydrogen peroxide
20 volume - Bleaching agent
Alcoholic or oleaginous solutions containing more than one API and are usually rubbed on the skin
Liniments
Liniments should not be applied to skin areas that are ____ or ____ to avoid excessive irritation
Liniments should not be applied to skin areas that arebruised or broken to avoid excessive irritation
Two types of Liniments
Alcoholic Liniment
Oleaginous Liniment
Alcoholic liniment
penetrating action; rubefacient and counterirritant
Oleaginous Liniments
For massage; less irritating
Solvent for
a) Fixed Oil: Peanut Oul, Almond Oil, Sesame Oil
b) Volatile Subs: Wintergreen, Turpentine
Liquid preparations composed of 4% pyroxylin dissolved in a solvent mixtures (Alcohol + Ether)
1:3 Alcohol-Ether
Collodions
Product of HNO3 + H2SO4 on cotton
Pyroxylin
Coat for bandages and stiched incisions to make them waterproof and protect against external stress
Flexible collodion
Components of Flexible Collodion
Collodion + 2% camphor + 3% Castor Oil
Camphor - Waterproof
Castor Oil - Flexibility
Flexible Collodion + 10% Salicylic Acid
Salicylic Acid Collodion
Keratolytic
Separation of medicinally active portions of plants or animal tissues by using selective solvent
Extraction
Solid ingredients are soaked in a stoppered container with a solvent and allowed to stand for a period of 3 days with frequent agitation
Maceration
Form of maceration using a gentle heat
Digestion
Maceration of solids for a short period of time with cold or hot boiling water
Infusion
Extracts water soluble and heat stable constituents by boiling in water for 15 minutes
Decoction
Extracts water soluble and heat stable constituents by boiling in water for 15 minutes
Decoction
Extracts water soluble and heat stable constituents by boiling in water for 15 minutes
Decoction
The ground solids are mixed with the appropriate quantity of the solvent and stand for 15 minutes then transferred to a percolator
Percolator
Pass a liquid through a solid material drop by drop
Concentrated preparations of vegetable or animal drugs
Extracts
Extracts are obtained by
Isolation of the active ingredient with suitable menstruum
Removal of solvent
Adjustment of the residual masses or powders
Forms of Extracts
Semiliquid Extracts
Pilular/Solid Extracts
Powdered Extracts
Liquid/syrupy extract; no solvent is removed
Semiliquid Extracts
Plastic masses intended for pills, ointments, and suppositories; nearly all solvent is removed
Pilular / Solid Extracts
Dry powders, intended for dry formulations; removed all solvents
Powdered Extracts
Alcoholic/hydroalcoholic solutions prepared from vegetable drugs or chemical substances
Tinctures
Alcohol Content of Tinctures
15 - 80%
Preparation of Tinctures
Percolation
Maceration
Belladonna is prepared by
Tincture
Percolation
Sweet Orange Peel and Compound Benzoin Tincture is prepared by
Maceration
Paregoric, USP
Camphorated Opium Tinxture
Opium Tincture, USP
Laudanum
Hydroalcoholic solutions from vegetable drugs (ONLY)
Fluidextracts
Fluidextracts is also known as
100% tinctures
Too potent and bitter
Preparation of Fluidextracts
Percolation
Processes of Percolation of Fluidextracts
PROCESS
A: Alcohol, Alcoholic water
B: Two menstruum
* Menstruum I: Glycerin or Acid
* Menstruum II: Mix of Alc & Water
C: Fractional/Divided (for volatile)
D: Boiling Menstruum
E: Modification of C; Alternate for A, B,