Capsules Flashcards
Solid dosage form in which one or more medicinal &/or inert substances are enclosed within a small edible shell usually made of gelatin
Capsules
Gelatin is obtained by ____________ of ____ obtained from skin, white connective tissue, and bones of animals
Gelatin is obtained by partial hydrolysis of collagen obtained from skin, white connective tissue, and bones of animals
Two Types of Gelatin
Type A - Acid Hydrolysis
Type B - Alkali Hydrolysis
Gelatin Grade is specified by
Bloom Strength
Bloom Strength of HCG
200 - 250g
Bloom Strength of Soft Gelatin Capsuke
150 g
Hard Gelatin Capsule considered vegetarian and can be used by people with restriction on consuming animal-based product
Hydroxypropyl methylcellulose (HPMC)
or STARCH
Storage condition of Capsules
10°C - 25°C and 35% - 45% RH
or
15°C - 30°C and <70RH
Dry Filled Capsule
Hard Gelatin Capsule
Main components of HGC
Gelatin
Sugar
Water
Colorant
Sulfur dioxide 0.15%
Titanium Oxide - Opacifying agent
Moisture Content of HGC
12-16% or 13-16% moisture
Method of Preparation
EXTEMPORANEOUS
Punch Method
Dosage form of choice for clinical trials
Hard Gelatin Capsule
Capsule sizes fit for Human use
SIze 000 (largest) to 5 (smallest)
Powder capacity of size 000
650-2000 mg
Powder capacity of size 5
60 -130mg
Capsule size for veterinary use
No 10. – No. 12
Soft elastic capsule
Soft Gelatin Capsule
contains non-aqueous liquids (vitamin e, cod liver oil, digoxin), suspensions, pastes, and dry solids
Soft Gelatin capsule
Main components of Soft Gelatin Capsule
Gelatin - Type B
Water
Plasticizer (Glycerin, Sorbitol)
Methyl/Propyl Paraben
Titanium oxide
Colorant, Flavoring, Sweetening Agent
Method of Preparation of SGC
Plate Process
Rotary Die Process
Encapsulation Process of SGC
- Preparation of Formulation
- Filling
- Sealing
- Cleaning & Polishing
Moisture content of SGC
6 - 10%
