Liquid Flashcards
Liquid preparations, that contain one or more chemical substances dissolved in a suitable solvent or mixture of mutually miscible solvents
Solutions
Advantages of Liquid Dosage Forms
Ideal for drugs that cannot be orally delivered
Delivery to the site of action is rapid
Ease of swallowing
A more uniform dosage form
Liquid dosage form of choice in certain conditions
Disadvantages of Liquid Dosage Forms
Liquid dosage forms are bulky
Udergo deterioration and loss of potency
Has water as an excellent medium for growth bacteria and mold
Most commonly used vehicle fo drug solutions
Water
Types of Water
Purified Water
Water for injection
Sterile Water for Injection
Bacteriostatic Water from Injection
Sterile Water for Inhalation
Sterile Water for Irrigation
Obtained by distillation, ion-exchange, reverse osmosis
Purified Water, USP
Purified Water, USP used in liquid dosage form, except ________ and ________ products
Purified Water, USP used in liquid dosage form, except parenteral and opthalmic products
Solvent used in large scale manufacture of injection
Water for Injection, USP
Water for Injection, USP is not ____ but should be ____
Water for Injection, USP is not sterile but should be pyrogen-free
Sterilized WFI
Sterile Water for Injection, USP
Solvent for reconstitution of multiple antibiotics
Sterile Water for Injection
Sterile Water for Injection with antimicrobial agent (benzyl alcohol)
Bacteriostatic Water for Injection
TF: Bacteriostatic Water for Injection can be used in neonates
FALSE
Bacteriostatic Water for Injection can NOT be used in neonates
SWFI that is not for parental or sterile dosage form
Sterile Water for Inhalation
SWFI for sterile irrigation, washing, rinsing, and dilution
Sterile Water for Irrigation
NOT FOR INJECTION
FOR IRRIGATION ONLY
Aqueous Solutions
Aromatic Water
Diluted Acids
Douches
Enemas
Mouthwashes
Gargles
Clear, saturated aqueous solutions of volatile oils or other aromatic substances
Aromatic Water/Medicated Waters
Use of Aromatic Water/Medicated Waters
Vehicle
Aq phase in suspension or emulsion
Problem in Aromatic Water/Medicated Waters
Salting out – insoluble layer at top
Methods of Preparation
Distillation/Cohobation
Solution Methid
Alternate Solution Method
Universal method but not practical/economical
Distillation/Cohobation
Distillation/Cohobation is used in preparation of
Orange Flower Water
Strong Rose Water
Hamamelis Water
Method where volatile oil is admixed with water
Solution Method
Method used in Chloroform Water
Solution method
Method of preparation with dispersant (Talc)
Alternate Solution Method
Method used in Cinnamon Water
Alternate Solution Method
Aqueous solutions of concentrated acid dissolve in purified water of suitable strength **10% w/v **
Diluted Acids
(except Acetic Acid, 6%)
Method used in preparation of Dil. Hydrochloric Acid, USP
Tx of achlorhydria
Diluted Acid
Cleansing or antiseptic agent directed against a part or into cavity of the body
Douches
Types of Douches
Eye douche
Pharyngeal douche
Nasal douche
Vaginal douche
Rectal solutions employed mainly to evacuate the bowel (evacuation enema) or to affect a local or systemic disease by absorption (retention enema)
Enemas / Clyster
Sodium phosphates enema (fleet enema)
Evacuation Enema
Retention Enemas
Hydrocortisone Enema - Local
Aminophylline Enema - Systemic
Sulfasalazine Enema
Solutions that are used to cleanse the mouth or treat diseases of the oral mucous membrane
Mouthwashes
Types of mouthwashes
Cosmetic - reduce bad breath
Therapeutic - reduce plaque, gingivits, dental caries, stomatitis
Used to diagnose oral cancer and lesions
Toluidine Blue Rinse
Used for treating pharynx and nasopharynx by forcing from lungs through solution held in throat
Gargles
