Granules

Question 1

prepared agglomerates of powders

Answer 1

Granules

Question 2

Pharmaceutical granules have a size range between

Answer 2

0.2 - 4 mm
1.Sieve Size: No. 4 – No. 12 (coarse to very coarse)

Question 3

Advantages of Granulation

Answer 3

Prevent segregration or demixing of the consituents of the powder mix
Improve the flow properties of the mix
Improve compaction characteristics of the mix
more stable to humidity; more easily wetted by liquids

Question 4

Methods of Granulation

Answer 4

Dry Granulation
Wet Granulation

Question 5

Dry Granulation is also known as

Answer 5

Precompression
Double Compression

Question 6

Used for drugs that do not compress well after wet granulations or those sensitive to heat and moisture

particles are aggregated using high pressure

Answer 6

Dry Granulation

Question 7

A large tablet (Slugs) is produced which is broken via milling to produce granular materials.

Answer 7

Slugging / Rotary Compaction

Question 8

The powder is squeezed between two rollers to produce a sheet of material

Answer 8

Roller Compaction / Ribbon Blending

Question 9

Most widely used that involves massing of a mix of dry primary powder particles using a granulating fluid

Answer 9

Wet granulation

Question 10

Liquid is sprayed on suspended powders

Answer 10

Fluid Bed Granulation