Sterile Dosage Form

Question 1

Sterile Dosage Forms

Answer 1

Ophthalmic Solutions
Irrigation Fluids
Dialysis Solution
Parenteral Solutions

Question 2

Injectable routes of administration and denotes routes of administration other than the oral route

Answer 2

Parenteral

Question 3

Advantages of Parenteral Dosage Form

Answer 3

Alternative when pt is unable to orally take drugs
For drugs inactivated by gastric acid/first pass effect
Action is required immediately

Question 4

Official Types of Injections

Answer 4

• Injection
• For Injection
• Injectable Emulsion
• Injectable Suspension
• For Injectable Suspension

Question 5

Liquid preparations that are drugs substances or solutions

Answer 5

Injection

Insulin Injection, USP

Question 6

Dry solids that, upon addition of suitable vehicles, yield solutions conforming in all respects to the requirements for Injections

Answer 6

For Injection

Cefuroxime for injection,USP

Question 7

Liquid preparation of drug substance dissolved or dispersed in a suitable emulsion medium

Answer 7

Injectable emulsion

Propofol, USP

Question 8

Liquid preparation of solid suspended in a suitable liquid medium

Answer 8

Injectable suspension:

Methylprednisolone Acetate Suspension, USP

Question 9

Dry solid that, upon addition of suitable vehicle, yields preparation conforming in all respects to the requirements for injectable suspensions

Answer 9

For injectable suspension

Imipenem and Cilastatin for injectable suspension, USP

Question 10

Solvents and Vehicles for Injections

Answer 10

Water: WFI, SWFI, BWFI
NaCl Injection
Ringer’s Injection
Lactated Ringer’s Injection

Question 11

Ringer’s Injection Components

Answer 11

Ringer’s Injection
NaCl, KCl, CaCl2 (electrolyte replenisher)

Question 12

Lactated Ringer’s Injection Components

Answer 12

NaCl, KCl, CaCl2, Na lactate – systemical alkalizer

Question 13

Non-Aqueous Vehicles

Answer 13

Fixed Vegetable Oils
Alcohol, glycerin, Ethyl Oleate, Isopropyl Myristate

Question 14

Parenteral Administration Routes

Answer 14

• Intravenous (IV)
• Intramuscular (IM)
• Subcutaneous (SC/SQ)
• Intradermal (ID)
• Intraarterial
• Intracardiac
• Intraspinal
• Intrathecal
• Intraarticular
• Intrasynovial
• Epidural

Question 15

Most important and most common parenteral administration with immediate therapeutic effect

Answer 15

Intravenous

Angle: 25

Question 16

Mid deltoid, Gluteus medius; for prolonged/delayed absorption

Answer 16

Intramuscular

Angle: 90

Question 17

Injection into the most superficial skin layer; skin test

Answer 17

Intradermal

Angle: 10-15

Question 18

Injection directly into the heart

Answer 18

Intracardiac

Question 19

Injection directly into an artery;
Radiopaque materials, thrombolytic agents, antineoplastic agents

Answer 19

Intraarterial

Question 20

Injection of large volumes of a solution onto the SC tissues to provide a continuous drug supply; antibiotic administration in children

Answer 20

Hypodermoclysis

Question 21

Injection into Joint space

Answer 21

Intra-articular

Corticosteroids

Question 22

Injection into the joint fluid

Answer 22

Intrasynovial

Question 23

Injection into the spinal fluid

Answer 23

Intrathecal

Cancer chemotherapy, antibiotics

Question 24

Injection near dura mater of CNS; used during childbirth

Answer 24

Epidural

Local anes, narcotics