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DDS > Aerosols > Flashcards

Aerosols Flashcards

1
Q

Products which depend upon the power of a liquefied or compressed gas to dispense active ingredient/s in a finely dispensed mist, foam, or semisolid

A

Aerosols

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2
Q

Advantages of Aerosols

A
  • Rapid onset of action
  • Prevent first-pass effect, avoidance of GIT degradation
  • Minimize ADRs due to lower dose
  • Allows dose titration & ideal for prn medication
  • Alternate route to prevent chemical & physical interactions w/ other drugs given concurrently
  • Useful when oral & parenteral administration is not suitable
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3
Q

Pharmaceutical aerosols intended for administration as fine, solid particles, or as liquid mists via, the respiratory system or nasal passages

A

Metered Dose Inhalers (MDIs)

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4
Q

Particle Size of MDIs

A

<10micrometer, usually 3-6 micrometers for maximum therapeutic response

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5
Q

Consists of solutions of active ingrediens in pure propellant & solvents

A

Solution Aerosols

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6
Q

The active ingredients are suspended or dispersed throughout the propellant/s or propellant & sovents phase

A

Dispersions or Suspensions (powder aerosols)

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7
Q

Can be dispersed as a spray, stable foam, or quick-braking foam

A

Emulsions

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8
Q

Depend on nitrogen to push content form package

A

Semisolid Preparations

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9
Q

Aerosol Systems

A

Two-phase Systems
1. Liquid Phase (liquefied propellant & product concentrate)
2. Vapor Phase

Three-phase Systems
1. Liquid Propellant
2. Product Concentrate
3. Vapor Phase

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10
Q

Commonly used when referring to the aerosol container or completed product

A

Pressurized Package

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11
Q

Aerosols used to provide an airborne mist

A

Space Sprays

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12
Q

Aerosols intended to carry the active ingredient to a surface

A

Surface Sprays (Surface Coatings)

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13
Q

Agent responsible for developing the pressure within an aerosol container and expelling the product when the valve is opened

A

Aerosol propellant

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14
Q

Liquefied Gases

A
  • Saturated HC (N-Butane, Propane)
  • Chlorofluorocarbons (CFCs) – phased out Dichlorodifluoromethane
  • Dichlorotetrafluoroethane
  • richloromonofluoromethane
  • Dimethy Ether
  • Hydorflurocarbons
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15
Q

Compressed Gases

A

Carbon Dioxide
Nitrogen Gas
Nitrous Oxide

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16
Q

active ingredient of the aerosol combined w/ the required adjuncts, such as antioxidants, surface active agents, & solvents, to prepare a stable & efficacious product

A

Product Concentrate

17
Q

Aerosol Container

A

(a) Tin - plated steel; light & relatively inexpensive

(b) Aluminum - preferred for use w/ most MDIs, strong & less reactive than the other metals

(c) Glass - high aesthetic value & minimal incompatibilities; use is limited to products w/ low pressure & propellant percentage

18
Q

Most basic part through which the contents of the package are emitted; regulates the flow of product from the container

A

Valve

19
Q

Permit expulsion of the contents of the can in the desired form at the desired rate, & in the case of metered valves, in the proper amount of dose.

A

Valve Assembly

20
Q

Parts of Aerosol Valve Assembly

A

Actuator
Stem
Gasket
Spring
Mounting Cup
Housing
Dip Tube

21
Q

Part of Valve assembly being pressed for emission of the product

A

Actuator

22
Q

Part of Valve assembly which supports the actuator & delivers the formulation in the proper form to the chamber of the actuator

A

Stem

23
Q

Part of Valve assembly which prevents leakage of contents

A

Gasket

24
Q

Holds the gasket in place & is the mechanism by which the actuator retracts when pressure is release, returning the valve to the dose position

A

Spring

25
Q

Attached to the aerosol can or container, hold the valve in place

A

Mounting cup

26
Q

Supports actuator, stern, and dip tube

A

Housing

27
Q

Extends from the housing down into the product; brings the formulation form the container to the valve

A

Dip Tube

28
Q

Method of Filling Aerosols (Filling Operations)

A

Cold Filling
Pressure Filling

29
Q

Both the product concentrate & propellant must be cooled to -34.5C to -40C (-30F to -40C)

A

Cold Filling

30
Q

The products is quantitatively placed in the aerosol container, the valve assembly is inserted & crimped into place, & the liquefied gas, under pressure, is metered into the valve stem form a pressure burette.

A

Pressure Filling

DDS (18 decks)

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