Tablet Flashcards
Solid dosage form that contain active ingredients & excipients prepared by either molding or compression
Tablets
Most common
Most Stable
Most tamper-proof
Dosage form
Tablet
Advantages of Tablets
Precision and Low control variability
Low Manufacturing cost
Easy to package and ship
Appropriate for special release form
Simple to identify
Essentially tamper-proof
Disadvantages of Tablets
Good compatiblity is required
Resist compression
Requires encapsulation before compression
Tablet Types and Classes
Tablets for oral ingestion
Tablets used in oral cavity
Tablets used to prepare solution
Tablets formed by compression and in simplest form, contain no special coating
Conventional Compressed Tablets
Compressing additional tablet granulation on previosuly compressed granulation
Multiple Compressed Tablets - Layered Tablet
Compressing another granulation layer/outer shell around the preformed tablet
Multiple Compressed Tablets: Layered Tablet
Compressing another granulation layer/outer shell around the preformed tablet
Multiple Compressed Tablets: Press coated Tablet/Dry coated tablet or Compression Coated
Use of Multiple Compressed Tablets
Separate incompatible ingredients
Produce prolonged or repeated release profiles
Use of Multiple Compressed Tablets
Separate incompatible ingredients
Produce prolonged or repeated release profiles
Compressed talets coated by sugar solution
Sugar Coated Tablet
Sugar Coated Tablet
Most elegant solid dosage form
Most difficult and time consuming to produce
50 -100% increase in size and weight
Use of Sugar Coated Tablet
To improve appearance
Mask unpleasant taste or smell
Protect from Oxidation
Compressed tablets coated w/ a thin layer of a insoluble or soluble polymer
2 - 3% increase in weight
Film Coated Tablets
Use of Film Coated Tablets
Protect drug from atmospheric conditions
Compressed tablets coated with substances that resist solution in gastric fluid but disintegrate in intestine
Delayed Action tablet
Enteric Coated Tablets
Use of Enteric Coated Tablet
To protect the drug which are inactivated destroyed in stomach
Enteric coating
Shellac
Cellulose Acetate Pthalate (CAP)
Intended to be chewed and swallowed
Chewable Tablets
Diluent used in Chewable Tablets
Mannitol
Commonly used for multivitamin tablets and for antacids, antibiotics
Chewable Tablets
Useful for children and elderly who is hvaing difficulty swallowing
Chewable Tablet
Tablets are placed under the tongue and dissolved rapidly
Sublingual Tablet
Tablets designed to dissolve slowly in the mouth between the cheek and gingiva
Buccal tablets
Use of Sublingual and Buccal tablet
Suitable for drugs that does not absorbed very well in stomach
Avoid first pass metabolism
Slow dissolving tablet prepared by molding or compression to produce local/systemic effect
Lozenges and Troches
Molded Lozenge
pastilles
Lozenge + Stick
Lollipop
Compressed lozenges
Troches
Use of Lozenges and Troches
Better patient compliance
Avoide First pass
Tablets containing an organic acid and carbonate salt along with API, and dissolved in water
Effervescent Tablet
Effervescent tablet composition
Tartaric Acid
Citric Acid
NaHCO3
Advantages of Effervescent Tablet
Improves palatability and faster absorption
Tablets containing large amounts of highly potent drug substances and supplied for Extemporaneous Compounding of the pharmacist
Dispensing tablet/Compounding Tablet
Advantages of Dispensing tablet
Can extemporaneously prepared according to requirement of patient
Soft, readily soluble tablets, used by physician in preparation of parenteral solution
Hypodermic Tablets
Tablets prepared by molding and are very soft and disintegrate quickly
Molded tablet/tablet Triturates
Drug product that alter the rate or timing of drug release
Modified Release Dosage Form
Abrupt, uncontrolled release of a large amount of drug
Dose dumping
Types of Modified Release Dosage Forms
a. Extended release (Controlled release, sustained release)
b. Deleayed release
c. Repeat Action
d. Targeted Release
Dosage form that maintains the therapeutic blood or tissue levels of the drug for a prolonged period
Provides a prompt-desired effect followed by a gradual release of remaining amount
Extended release
Releases the drug at a constant rate and provide plasma concentrations that remain invariant with time
Controlled-release
Follows Zero-order
Releases an initial release of drug sufficient to provide a therapeutic dose after administration, then a gradual release over an extended period
Sustained release
Follow first-order
Affected by environment
Designed to release the drug at a time other than promptly after administration
Deleayed release Dosage Forms
Individual dose is released after administration, and second dose is released at intermittent intervals
Repeat Action
1st dose - Immediate release
2nd dose - delayed release
Drug release is direct toward isolation or concentrating a drug in a body, tissue, or site for abs or action
Targeted-release
