TCA cycle Flashcards
what is the main goal of TCA cycle?
to produce NADH and FADH2
what is the rate limiting enzyme of TCA cycle?
isocitrate dehydrogenase
what are the steps of the TCA cycle?
- acetyl - CoA
- citrate
- isocitrate
- alpha ketoglutarate
- succinyl- CoA
- succinate
- fumarate
- malate
- oxaloactetate
what will activate the TCA cycle?
ADP
what will inhibit the TCA cycle?
ATP
NADH
FADH2
what does succinate dehydrogenase produce?
FADH2
what does Alpha - ketoglutarate dehydrogenase and isocitrate dehydrogenase and malate dehydrogenase produce?
NADH
what is involved in acetyl- coA to citrate?
citrate synthase
what is involved in citrate to isocitrate?
aconitase
what is involved in isocitrate to alpha- ketoglutarate?
isocitrate dehydrogenase
what is involved in alpha- ketoglutarate to succinyl- CoA?
alpha- ketoglutarate dehydrogenase
what is involved in succinyl- CoA to succinate?
succinate thiokinase
what is involved in succinate to fumarate?
succinate dehydrogenase
what is involved in fumarate to malate?
fumarase hydrodase
what is involved in malate to oxaloacetate?
malate dehydrogenase
How does thermogenin, a protein expressed in brown adipose cells, generate heat?
uncouples electron transport
Which enzyme in the TCA cycle is inhibited by the toxin fluroacetate?
aconitas
During the first stage of acetyl CoA synthesis by the pyruvate dehydrogenase complex; what is removed from pyruvate?
carbon dioxide
In reactive oxygen scavenging; which reactive centre does peroxidase catalase use to convert two hydrogen peroxide ions to water and oxygen?
iron hem group
Which complex in the electron transport chain is inhibited by cyanide and carbon monoxide?
comple IV
For each molecule of glucose that enters glycolysis, how many times can the TCA cycle proceed?
2
