cholesterol synthesis Flashcards
1
Q
what are cholesterol?
A
lipid and hydrophobic
2
Q
what are the functions of cholesterol?
A
vitamin D precursor
production of bile salts
steroid hormones
membrane stability
3
Q
what is the rate limiting step for cholesterol synthesis?
A
HMG-coA reductase
4
Q
where does cholesterol synthesis occurs ?
A
adrenal glands
liver
intestines
5
Q
what does medication for cholesterol synthesis inhibits?
A
HMG-cOA reducase synthesis
6
Q
where does the 3 hydroxyl- 3 methy occur and produce?
A
in the mitochondria
produce ketone bodies
7
Q
where does HMG-COA reductase occurs and what does it produce?
A
occurs in the cytosol
produces melvanic acid
8
Q
what are the steps of the cholesterol synthesis?
A
- Acetyl- COA
- mevallonate
- 6 isopentyl-pyrophate
- farnseyl pyrophosphate 15c
- squalene
- squalene epoxide
- lonosterol
- cholesterol
9
Q
what is squalene activated to?
A
squalene epoxide
10
Q
what occurs when farnseyl pyrophosphate 15c to squalene?
A
condensation
