ketone body synthesis Flashcards
1
Q
what is ketone body synthesis?
A
it is a process that produces ketone bodies by breaking down fatty acids and ketogenic amino acids.
2
Q
what are ketone bodies synthesised from?
A
acteyl- coenzyme A
3
Q
what is acetyl- coA a product of?
A
mitochondrial beta oxidation of fatty acids
4
Q
what are ketone bodies?
A
they are energy sources
5
Q
where does ketone body synthesis mainly occur?
A
liver hepatocytes
6
Q
what are the steps of ketone body synthesis?
A
- 2 acetyl-CoA from beta oxidation
- acetoacetyl- coA
- HMG- CoA
- acetoacetate - b hydroxybutarate or acetone.
7
Q
what enzyme is involved in 2 acteyl- coA to acetoacetyl coA?
A
3- ketothiolase
8
Q
what enzyme is involved in acetoacety- coA to HMG-coA?
A
HMG CoA synthase
9
Q
what enzyme is involved In HMG CoA to acetoacetate?
A
HMG coA cleavage enzyme and D3 hydroxybutarate dehydrogenase
