Sympathomimetics Flashcards
Direct Acting Non-selective
B1=B2 > alpha
Epinephrine
Direct Acting Non-selective
alpha >B1»_space; B2 almost negligible
1st line treatment for SEPTIC SHOCK
Norepinephrine
Direct Acting Non-selective
D1,a1,a2,B1,B3
for shock (+) renal shutdown
cardiogenic shock
Dopamine
Direct Acting Non-selective
B1, B2, B3
Isoproterenol
Direct Acting
alpha 1 agonist
vasoconstriction, increases BP
for decongestant
SE: rebound nasal congestion (rhinitis medicamentosa)
Phenylephrine
Pseudoephedrine
Midodrine
Oxymetazoline
Tetrahydrozoline
Naphazoline
Xylometazoline
Direct Acting
alpha 2 agonist
decreases central sympathetic outflow – (-) of sympathetic tone and reduced BP
for HPN
SE: rebound HPN
Clonidine
Direct Acting
alpha 2 agonist
decreases central sympathetic outflow – (-) of sympathetic tone and reduced BP
for preeclampsia, gestational HPN
SE: sedation, hemolytic anemia (+ Coombs test)
Methyldopa
Guanfacine
Guanabenz
Dexmetomidine - causes conscious sedation
Tizanidine - muscle relaxant
Direct Acting
alpha 2 agonist
decrease secretion of aqueous outflow
for Glaucoma
Apraclonidine
Brimonidine
Ocular administration causes MYDRIASIS without cycloplegia (loss of accommodation)
PHENYLEPHRINE
Used for the treatment of orthostatic hypotension
Midodrine
Direct Acting
beta 1 agonist
increases HR and contractility
cardiogenic shock
SE: arrythmias, tachyphylaxis, eosinophilic myocarditis
Dobutamine
Direct Acting
BETA
bronchodilator
asthma attacks
tocolysis - RIT
SE: tachycardia, tremors
Salbutamol
Albuterol
Ritodrine
Isoxsuprine
Terbutaline
Metaproterenol
Indirect Acting
Displaces stored catecholamines from nerve endings
for anorexiant, ADHD, narcolepsy
Amphetamine
Methamphetamine
Blocks NE reuptake (NET) and dopamine reuptake (DAT)
Cocaine
Displaces stored catecholamines from nerve endings
no clinical used but found in fermented foods
Tyramine
