Drugs for Amebiasis

Question 1

LUMINAL AMEBICIDES

Answer 1

DIP

Diloxanide Furoate
Iodoquinol
Paromomycin

Question 2

(-) protein synthesis

Used w/ Metronidazole in the treatment of intestinal and extraintestinal amebic infections

Answer 2

Paromomycin

Question 3

Reactive reduction by ferrodoxin forming free radicals that disrupts ETC

TISSUE AMEBICIDE

Answer 3

Metronidazole

Question 4

Treatment for Asymptomatic, Intestinal Amebiasis

Answer 4

LUMINAL AGENT

Diloxanide furoate, Iodoquinol or Paromomycin

Question 5

Treatment for Mild-Moderate Amebiasis

Answer 5

Metronidazole + Luminal Agent

Tinidazole or Tetracycline or
Erythromycin + Luminal Agent

Question 6

Treatment for Severe Amebiasis

Answer 6

Metronidazole or Tinidazole + Luminal Agent

Tetracycline or Emetine or Dehydroemetine + Luminal Agent

Question 7

The drug regimen most likely to be effective in treating severe extraintestinal disease in this patient is

(A) Chloroquine
(B) Diloxanide furoate plus iodoquinol
(C) Emetine plus diloxanide furoate plus chloroquine
(D) Pentamidine followed by mefloquine
(E) Tinidazole plus diloxanide furoate

Answer 7

(E) Tinidazole plus diloxanide furoate

Question 8

55-year-old man presents with lower
abdominal discomfort, flatulence, and occasional diarrhea. A diagnosis of intestinal amebiasis is made, and E histolytica is identified in his diarrheal stools. An oral drug is prescribed, which reduces his intestinal symptoms. Later he presents with severe dysentery,
right upper quadrant pain, weight loss, fever, and an enlarged liver. Amebic liver abscess is diagnosed, and the patient is hospitalized. He has a recent history of drug treatment for a cardiac arrhythmia.

The preferred treatment that he should have received for the initial symptoms (which were indicative of mild-to moderate disease) is

(A) Diloxanide furoate
(B) Iodoquinol
(C) Metronidazole
(D) Metronidazole plus diloxanide furoate
(E) Paromomycin

Answer 8

(D) Metronidazole plus diloxanide furoate

Metronidazole plus a luminal amebicide is the treatment of choice in mild to moderate amebic colitis. Diloxanide
furoate (or iodoquinol, or paromomycin) can be used as
the sole agent in asymptomatic intestinal infection.

Question 9

TISSUE AMEBICIDES

Answer 9

Metronidazole
Tinidazole
Secnidazole
Nitazoxanide
Emetine
Dehydroemetine