Antipsychotic Agents and Lithium Flashcards
TYPICAL (CLASSICAL) ANTIPSYCHOTICS
blocks D2 > 5 HT2a
addresses POSITIVE SYMPTOMS - hallucinations
Phenothiazines
Thioxanthines
Butyrophenones
High potency typical antipsychotics
higher chances of EPS
Haloperidol
Droperidol
Low potency typical antipsychotics
cause sedation and postural hypotension
Thioridazine
Chlorpromazine
ATYPICAL (CLASSICAL) ANTIPSYCHOTICS
blocks 5 HT2a > D2
addresses BOTH positive and negative effects of Schizophrenia
Heterocyclics
lesser propensity to cause EPS but higher propensity to cause metabolic derangements (weight gain, endocrine problems)
Typical Antipsychotics
PHENOTHIAZINES
for schizophrenia and other psychotic disorders
manic phase
Chlorpromazine Levomepromazine Prochlorperazine Promethazine Thiothexene Flupentixol
Typical antipsychotic that can cause CORNEAL and LENS DEPOSITS
Chlorpromazine
Typical Antipsychotics
PIPERIDINE
for schizophrenia and other psychotic disorders
Thioridazine
Fluphenazine
Perphenazine
Trifluoperazine
Typical antipsychotic that can cause RETINAL DEPOSTIS and QT PROLONGATION
Thioridazine
Typical Antipsychotics
BUTYROPHENONE
for schizophrenia, Huntington and Tourette’s syndrome
Haloperidol
Droperidol
Major tranquilizer given IM
SE: Has the HIGHEST POTENTIAL for EPS and neuroleptic malignant syndrome
Haloperidol
ATYPICAL ANTIPSYCHOTICS
Clozapine Olanzapine Quetiapine Risperidone, Paliperidone Ziprasidone Aripiprazole
Atypical Antipsychotics
DOC for refractory and suicidal schizophrenia
Clozapine
SE:
AGRANULOCYTOSIS
Atypical Antipsychotics with HIGHEST WEIGHT GAIN
Clozapine
Olanzapine
Atypical Antipsychotics has MINIMAL or NO INCREASES in prolactin and has REDUCED RISK for EPS
Olanzapine
Quetiapine
Aripiprazole
Atypical Antipsychotics
for bipolar (manic episode), sleep paralysis and maintenance
Quetiapine
SE:
cataracts
priapism
QT prolongation
