Drugs for HIV

Question 1

Highly Active Antiretroviral Therapy (HAART)

Answer 1

2 NRTIs PLUS 1 protease inhibitor

Question 2

Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

(-) HIV reverse transcriptase AFTER phosphorylation by cellular enzymes

Answer 2

NRTIs

Zidovudine
Abacavir
Didanosine
Emtricitabine
Lamivudine
Stavudine
Tenoforvir
Zalcitabine

Question 3

SE of Abacavir

Answer 3

Hypersensitivity

Question 4

SE of Didanosine

Answer 4

Pancreatitis

Question 5

SE of Zidovudine and Zalcitabine

Answer 5

Peripheral neuropathy

Question 6

Non - Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

(-) HIV reverse transcriptase
NO PHOSPHORYLATION REQUIRED

Answer 6

NNRTIs
-VIR in the middle
NEEDR

Nevirapine
Efavirenz
Etravirine
Delavirdine
Rilpivirine

Question 7

Protease Inhibitors

(-) viral protein processing

Answer 7

PROTEASE INHIBITORS

• NAVIR
• PREVIR

Indinavir [C]
Amprenavir
Atazanavir
Darunavir
Indinavir
Lopinavir
Nelfinavir
Ritonavir
Saquinavir
Tipranavir
Fosamprenavir
Boceprevir
Telaprivir

Question 8

Entry Inhibitors

Binds to gp41 subunit of the viral envelope glycoprotein preventing fusion of viral and cellular membranes

Answer 8

Enfuvirtide

Question 9

CCR5 Receptor Antagonist

blocks viral attachment via transmembrane chemokine receptor CCR5

Answer 9

Maraviroc

Question 10

Integrase Inhibitors

Answer 10

INTEGRASE INHIBITOR
-GRAVIR

Raltegravir
Dolutegravir