Opioid Analgesics and Antagonists Flashcards
FULL AGONIST
FHM3
FENTANYL- MOST POTENT
Sufentanil, Alfentanil, Remifentanil, Ohmefentanyl
HEROIN
MORPHINE
Hydromorphone
Oxymorphone
METHADONE
Luvomethadyl acetate
Levorphanol
MEPERIDINE
DOC for MI pain
MORPHINE
DOC for OPIOID WITHDRAWAL
METHADONE
DOC for BILIARY PAIN/PANCREATIC PAIN
MEPERIDINE
Fentanyl + Droperidol
neurolepticanalgesia
Actions of Morphine
HEC of a DREAM
Histamine release
Emesis
CV hypotension
Depression of CNS, GIT, cough center Respiratory Depression Euphoria Analgesia Miosis
PARTIAL AGONISTS - also used as antitussives
HYDROCODONE
OXYCODONE
DEXTROMETHORPHAN
CODEIN
WEAK AGONISTS
PROPOXYPHENE
MIXED-AGONIST ANTAGONISTS
partial mu receptor agonist
antagonist at kappa and delta receptors
BUPRENORPHINE Nalbuphine Butorphanol Pentazocine Levallorphan
ANTAGONISTS
NALOXONE
Naltrexone
Nalmefene
Methylnatrexone
DUAL ACTING
weak agonist at mu receptor
(-) neuronal reuptake of serotonin and NE
(-) pain neurotransmission
for moderate pain, adjuncts to opioid
TRAMADOL
Tapentadol
SE: seizures nausea dizziness pruritus constipation
NATURAL
Morphine
Codeine
Thelaine
SEMI SYNTHETIC
Heroin Apomorphine Hydrocodone Oxycodone Hydromorphone Oxymorphone
PURELY SYNTHETIC
Methadone Loperamide Meperidine Fentanyl Tramadol Pentazocine
Full Agonists
PHENANTHRENES
strong agonist at mu receptors
for severe pain (MI, cancer, pulmonary edema)
Morphine
Hydromorphone
Oxymorphone
Heroin
Full Agonists
PHENYLPIPERIDINE
Fentanyl Sufentanil Alfentanil Remifentanil Ohmefentanyl
Opioid with the SHORTEST half life
Remifentanil (3-4 mins)
Opioid with the LONGEST half life
Buprenorphine (4-8 hrs)
Full Agonists
PETHIDINE
strong agonist at mu and kappa receptors
for postoperative shivering
Meperidine
SE:
seizures
delirium
does NOT cause miosis rather mydriasis
Meperidine + MAOI
Hyperpyrexic coma
Meperidine + SSRI
Serotonin syndrome
Full Agonists
PHENYLHEPTYLAMINES
strong agonist at mu receptors
NDMA antagonist
for opioid dependence
Methadone
Levomethadyl Acetate
Levorphanol
Mixed agonist and antagonist used for POSTOPERATIVE SHIVERING
Butorphanol
Mixed agonist and antagonist used for OPIOID WITHDRAWAL STATES
Buprenorphine
