Drugs for Gout

Question 1

Commonly used in the initial treatment of gout as the replacement for colchicine

Answer 1

Indomethacin

Question 2

MICROTUBULE ASSEMBLY INHIBITOR

Inhibits microtubule assembly and LTB4 production – decreased macrophage migration and phagocytosis

USES:
gout
familial Mediterranean fever

Answer 2

Colchicine

SE:
diarrhea 
N/V
abdominal pain
bone marrow depression
acute renal failure

NOT to be give in patients with eGFR<30

Question 3

Adverse effect which signals toxicity from colchicine

Answer 3

DIARRHEA

Question 4

URICOSURIC AGENTS

Compete with uric acid for reabsorption in the proximal tubules

Increase uric acid excretion

Answer 4

Probenecid

Sulfinpyrazone

Question 5

XANTHINE OXIDASE INHIBITORS

Active metabolite (alloxanthine) that IRREVERSIBLY inhibits Xanthine oxidase and lowers production of uric acid

USES:
1st line treatment - Chronic Gout
Tumor Lysis Syndrome

Answer 5

Allopurinol

Question 6

XANTHINE OXIDASE INHIBITORS

Nonpurine REVERSIBLE that is an inhibitor of xanthine oxidase

Lowers production of uric acid

USES:
1st line treatment - Chronic Gout
Tumor Lysis Syndrome
Allopurinol intolerance

Answer 6

Febuxostat