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Pharmacology > Antifungal therapy > Flashcards

Antifungal therapy Flashcards

1
Q

Lanosterol synthesis

(-) SQUALENE EPOXIDASE

A

Terbinafine

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2
Q

Cell Wall Synthesis

(-) synthesis of B glucan – (-) cell wall synthesis

A

ECHINOCANDINS
-fungin

Anidulafungin
Caspofungin
Micafungin

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3
Q

Ergosterol Synthesis

(-) LANOSTEROL – (-) ergosterol conversion

A

AZOLES

Clotrimazole
Fluconazole
Itraconazole
Ketoconazole
Miconazole
Voriconazole
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4
Q

Cell Membrane Integrity

BINDS to ergosterol – forms membrane PORES – LEAKAGE of ELECTROLYTES

A

POLYENES

Amphotericin B - systemic
Nystacin - superficial

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5
Q

Nucleic Acid Synthesis

(-) DNA and RNA BIOSYNTHESIS via conversion into 5-FU by CYTOSINE DEAMINASE

A

Flucytosine

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6
Q

Interferes MICROTUBULE function

A

Griseofulvin

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7
Q

Used for CRYPTOCOCCAL MENINGITIS

Alternative to Amphotericin B in the treatment of C. neoformans

A

Fluconazole

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8
Q

SE of Echinocandin

A

fever
flushing (histamine release)
elevated liver enzymes

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9
Q

SE of Amphotericin B

A

NEPHROTOXIC

infusion reactions - chills, fever, muscle spasms

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10
Q

Has the BROADEST spectrum triazole

A

Posaconazole

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Pharmacology (72 decks)

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