Prostaglandin and Other Eicosanoids

Question 1

Eicosanoids are group of endogenous FA derivatives produced from

Answer 1

Arachidonic acid

Question 2

Major families of eicosanoids

Answer 2

straight chain derivatives - LEUKOTRIENES

cyclic derivatives - PROSTACYCLIN, PROSTAGLANDINS, THROMBOXANE

Question 3

PGE1

Answer 3

vascular smooth muscle relaxation

protective effects on gastric mucosa

maintains PDA

Question 4

PGE1 Analog

Answer 4

M1soprostol
Gemeprost
Alprostad1l

Question 5

LTB4 (chemotactic factor)

Answer 5

leukocyte chemotaxis

Question 6

LTC4 and LTD4

Answer 6

bronchoconstrictors
slow reacting substance of anaphylaxis

Question 7

PGE2

Answer 7

vascular smooth muscle relaxation

maintains PDA

increases uterine tone

Question 8

PGE2 Analog

Answer 8

Dinoprostone
Sulprostone

Question 9

PGI2

Answer 9

vascular smooth muscle relaxation (peripheral, pulmonary, coronary)

Question 10

PGF2a

Answer 10

increases uterine tone

decreases IOP

Question 11

PGF2a Analog

Answer 11

Carboprost
Latanoprost

Question 12

PGI2 Analog

Answer 12

Epoprostenol
Beratoprost
Iloprost
Treprostinil

Question 13

Leukotriene Antagonist

Answer 13

Zileuton
Montelukast
Zafirlukast

Question 14

Prostaglandin Antagonist

Answer 14

Corticosteroids
NSAIDS

Question 15

Causes increased HCO3 and mucus secretion in stomach

Uterine contraction

for PUD, prevention of NSAID induced gastric mucosal injury, abortifacient

SE: Moebius sequence (teratogenic effect)

Answer 15

PGE1 Analog

Misoprostol
Gemeprost

Question 16

Vascular smooth muscle relaxation and vasodilation

for maintenance of PDA
erectile dysfunction

Answer 16

PGE1 Analog

Alprostadil

Question 17

PGE2 Analog

Induction of labor (Cervical ripening), Abortifacient

Answer 17

Dinoprostone
Sulprostone

Question 18

PGF2a

Answer 18

Increases uterine tone
Decreases IOP

Question 19

PGF2a Analog

Uterine contraction
Control of postpartum hemorrhage
Abortifacient

SE: transient bronchoconstriction

Answer 19

Carboprost

Question 20

PGF2a Analog

Activates FP receptors
Increases outflow of aqueous humor
Reduces IOP

for Glaucoma

SE: alters color of the iris – permanent color change

Answer 20

Latanoprost

Question 21

PGI2

Answer 21

vascular smooth muscle relaxation (peripheral, pulmonary, coronary)

Question 22

PGI2 Analog

Activates IP receptors
Causes vasodilation
Reduces platelet aggregation

for pulmonary HPN

Answer 22

Epoprostenol
Beratoprost
Iloprost
Treprostinil

Question 23

Other Drugs Used for Erectile Dysfunction

PDE-5 Inhibitor

Answer 23

Sildenafil
Tadalafil
Vardenafil

do NOT take with nitrates – fatal hypotension