Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Prostaglandin and Other Eicosanoids > Flashcards

Prostaglandin and Other Eicosanoids Flashcards

1
Q

Eicosanoids are group of endogenous FA derivatives produced from

A

Arachidonic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Major families of eicosanoids

A

straight chain derivatives - LEUKOTRIENES

cyclic derivatives - PROSTACYCLIN, PROSTAGLANDINS, THROMBOXANE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

PGE1

A

vascular smooth muscle relaxation

protective effects on gastric mucosa

maintains PDA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

PGE1 Analog

A

M1soprostol
Gemeprost
Alprostad1l

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

LTB4 (chemotactic factor)

A

leukocyte chemotaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

LTC4 and LTD4

A

bronchoconstrictors
slow reacting substance of anaphylaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

PGE2

A

vascular smooth muscle relaxation

maintains PDA

increases uterine tone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

PGE2 Analog

A

Dinoprostone
Sulprostone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

PGI2

A

vascular smooth muscle relaxation (peripheral, pulmonary, coronary)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

PGF2a

A

increases uterine tone

decreases IOP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

PGF2a Analog

A

Carboprost
Latanoprost

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

PGI2 Analog

A

Epoprostenol
Beratoprost
Iloprost
Treprostinil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Leukotriene Antagonist

A

Zileuton
Montelukast
Zafirlukast

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Prostaglandin Antagonist

A

Corticosteroids
NSAIDS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Causes increased HCO3 and mucus secretion in stomach

Uterine contraction

for PUD, prevention of NSAID induced gastric mucosal injury, abortifacient

SE: Moebius sequence (teratogenic effect)

A

PGE1 Analog

Misoprostol
Gemeprost

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Vascular smooth muscle relaxation and vasodilation

for maintenance of PDA
erectile dysfunction

A

PGE1 Analog

Alprostadil

17
Q

PGE2 Analog

Induction of labor (Cervical ripening), Abortifacient

A

Dinoprostone
Sulprostone

18
Q

PGF2a

A

Increases uterine tone
Decreases IOP

19
Q

PGF2a Analog

Uterine contraction
Control of postpartum hemorrhage
Abortifacient

SE: transient bronchoconstriction

A

Carboprost

20
Q

PGF2a Analog

Activates FP receptors
Increases outflow of aqueous humor
Reduces IOP

for Glaucoma

SE: alters color of the iris – permanent color change

A

Latanoprost

21
Q

PGI2

A

vascular smooth muscle relaxation (peripheral, pulmonary, coronary)

22
Q

PGI2 Analog

Activates IP receptors
Causes vasodilation
Reduces platelet aggregation

for pulmonary HPN

A

Epoprostenol
Beratoprost
Iloprost
Treprostinil

23
Q

Other Drugs Used for Erectile Dysfunction

PDE-5 Inhibitor

A

Sildenafil
Tadalafil
Vardenafil

do NOT take with nitrates – fatal hypotension

Pharmacology (72 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions