Sympathomimetic Drugs

Question 1

What are sympathomimetic drugs? Summarize them

Answer 1

Substances that mimic or modify the actions of exogenous catecholamines of the SNS

Question 2

Albuterol, Salmeterol, formoterol, and tertbutaline cause what action? (Beta)
-Cardiovascular effects?
-Indications?

Answer 2

Beta 2 > Beta 1
- Mild increase in HR
- Asthma, COPD, and preterm labor

Question 3

Clonidine and guanfacine have what action?
-Action of these drugs?
-Indications?

Answer 3

Alpha 2
-Lowers blood pressure
- HTN, ADHD, Tourette’s, and drug withdrawal

Question 4

Dobutamine has what MOA?
-Effects?
-Indications?

Answer 4

B1 > B2, alpha; Inotropic effects > chronotropic
-No change or mild decrease in BP, raises HR and cardiac output
-Heart failure, cardiogenic shock, cardiac stress testing

Question 5

Dopamine has what action?
-Effects?
-Indications

Answer 5

D1 = D2 > B > A; Chronotropic effects at lower doses (B effect), vasoconstriction at high doses (a effect)

• Raises BP (at high doses), HR, CO

-Heart failure, cardiogenic shock, unstable bradycardia

Question 6

Epinephrine has what action?
-Effect?
-Indications?

Answer 6

B > a (at high doses a is more prominent)

-Raises BP (at high doses), HR, and CO

-Anaphylaxis, cardiac arrest, septic shock, post bypass hypotension, asthma

Question 7

Fenoldopam has what action?
-Effects?
-Indications

Answer 7

D1, vasodilators, natriuresis

-Raises CO and HR; Lowers BP

-Hypertensive crisis, post operative HTN

Question 8

Isoproterenol has what action sites?
-Effects
-Indications

Answer 8

B1=B2

-Raises CO and HR

-Bradycardia or heart block

Question 9

Methyldopa has what effects? Indications for it?

Answer 9

Lowers BP
indicated for HTN especially in pregnancy

Question 10

Midodrine has what action sites?
-Effects?
-Indications

Answer 10

a1

-Raises BP, lowers HR, no changes or decrease in cardiac output

• Autonomic insufficiency and symptomatic orthostatic hypotension

Question 11

Mirabegron has what action sites?
-Effect
-Indication

Answer 11

B3
-Raises BP
-Urinary urge incontinence or over active bladder

Question 12

Norepinephrine effect and indications?

Answer 12

Raises BP
Septic shock, neurogenic shock, hypotension

Question 13

Oxymetazoline has what effects and indications?

Answer 13

May raise BP

Epistaxis, rhinitis, sinusitis

Question 14

For what indications are amphetamines given?

Answer 14

ADHD, narcolepsy, and obesity

Question 15

Ephedrine indications specifically is what for rhinovirus?
-Causes what effects

Answer 15

Nasal congestion
-Reduces hyperemia and edema
-Opens nasal meatus and eustachian tubes