Statins

Question 1

Overview: Half life of:
1.Atorvastatin
2.Simvastatin
3.Pravastatin
4.Lovastatin
5.Fluvastatin
6.Pitavastin
7.Rosuvastatin

Answer 1

1. 15-30 hrs
2. 2-3 hrs
3. ~2 hrs
4. 3 hrs
5. .5-2.5 hrs
6. 12 hrs
7. 19 hrs

Question 2

What’re the pharmacodynamics of Statins?

Answer 2

Large decrease in LDL cholesterol
Increase if HDL cholesterol
Decrease in triglyceride level

Question 3

What’re the Pleiotropic effects of statins?

Answer 3

Decrease in CRP

Increased plaque stabilization

Increase anti inflammatory effect

Antioxidant effect and improved endothelial function of coronary arteries

Question 4

Adverse effects of statins?
-Muscular <—

Answer 4

Statins may decrease the synthesis of ubiquinone
- Myalgia, myositis, and may progress to rhabdomyolysis (may discontinue if rhabdo. Occurs)

Question 5

What’re some indications of giving statins?

Answer 5

Patients with CAD, CVD, LDL cholesterol above 190 mg/dL, patients with diabetes