Antiarrhythmics

Question 1

How many subcategories of class 1 antiarrhythmics are there?

Answer 1

3

Question 2

Class 1 antiarrhythmics are what drug group? (What do they effect?)

Answer 2

Fast sodium channel blockers

Question 3

What’re some examples of class 1A antiarrhythmics?

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Answer 3

Quinidine
Procainamide
Disopyramide
Ajmaline

Question 4

What’re some examples of class 1B antiarrhythmics?

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Answer 4

Lidocaine
Mexiletine
Phenytoin

Question 5

What’re some class 1C antiarrhythmics?

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Answer 5

Flecainamide
Propafenone

Question 6

For what indications are class 1A antiarrhythmics?

Answer 6

PSVT, Afib, and ventricular arrhythmias

Question 7

When are class 1B antiarrhythmics indicated?

Answer 7

Ventricular arrhythmias (especially after an MI) and digitalis-induced cardiac arrhythmias

Question 8

For what indications are class 1C antiarrhythmics used for?

Answer 8

PSVT, afib, and a flutter

Question 9

What’re some adverse effects of class 1A antiarrhythmics

Answer 9

QT prolongation (torsades)

Cinchonism

Thrombocytopenia

Drug induced lupus

Anticholinergic effects

Question 10

What is cinchonism?
-What drug causes it?

Answer 10

Headache, hearing/vision loss, tinnitus, psychosis and conginitive impairment
-Associated with quinidine use

Question 11

What does procainamide cause that’s irreversible?

Answer 11

Drug induced lupus

Question 12

What does disopyramide cause as an adverse effect?

Answer 12

Heart failure and anticholinergic effects

Question 13

What’re some adverse effects for class 1B antiarrhythmics?

Answer 13

Dizziness, nausea
Seizures
AV conduction block

Question 14

What’re some adverse effects of class 1C antiarrhythmics?
-Contraindicated when?

Answer 14

Possible QT prolongation due to increased QRS duration
-Contra ind. following an MI

Question 15

What are the class II antiarrhythmic drugs?

Answer 15

Beta blocker

Question 16

What are class III antiarrhythmic drugs?

Answer 16

Potassium channel blockers

Question 17

MOA of class III antiarrhythmics?

Answer 17

They Prolong QT interval

Question 18

What’re some class III antiarrhythmic drugs?

Answer 18

Dronedarone
Sotalol
Bretylium
Ibutilide
Dofetilide

Question 19

What are the class IV antiarrhythmic drugs?

Answer 19

Calcium channel blockers

Question 20

Class V antiarrhythmic drugs are ______ in function

Answer 20

Variable

Question 21

What are the class V antiarrhythmic drugs?

Answer 21

Adenosine, magnesium sulfate, Digoxin, and Ivabradine

Question 22

Adenosine adverse effects?

Answer 22

Chest pain, flushing, hypotension, bronchospasm, and sense of impending doom

Question 23

Magnesium sulfate adverse effects?

Answer 23

Hypotension, asystole, drowsiness, flushing, loss of reflexes, and respiratory depression

Question 24

Digoxin adverse effects?

Answer 24

Nausea, vomiting, abdominal pain, blurred vision with a yellow tint and halos

Question 25

Ivabradine adverse effects?

Answer 25

Vision changes (enhanced visual brightness), bradycardia, hypertension

Question 26

What is the indicated use of adenosine?

Answer 26

Diagnosis and termination of certain forms of PSVT

Question 27

What is the indication of magnesium sulfate?

Answer 27

Torsades de pointes
Digoxin toxicity

Question 28

What is indicated for use of digoxin?

Answer 28

Afib
A flutter
Chronic systolic heart failure

Question 29

Ivabradine indicated use is for?
-what chronic condition can it be used for?

Answer 29

Chronic stable coronary heart disease patients who can’t tolerate beta blockers
-Chronic HFrEF

Question 30

What’re some adverse effects of ivabradine?

Answer 30

Vision changes
Bradycardia
Hypertension

Question 31

All antiarrhythmics are also potentially?
-So when pushing via IV, what should always be done?

Answer 31

Proarrhythmic
-Constant cardiac monitoring

Question 32

What class of antiarrhythmics work best after an MI?
-Which class is contraindicated?

Answer 32

1B
-1C