Substance Use Disorder

Question 1

Behavior where person uses drug for personal satisfaction

Answer 1

Addiction

Question 2

Drug that has abuse liability

Answer 2

Controlled Substance

Question 3

State characterized by signs and symptoms when drug is withdrawn from chronic use

Answer 3

Dependence

Question 4

Synthetic derivative of a drug with slightly modified structure to try and avoid the schedules (illegal/fines) of controlled drugs

Answer 4

Designer Drug

Question 5

Decreased response to a drug, needed higher doses to achieve same effect

Answer 5

Tolerance

Question 6

Increased response with repetition of the same dose of the drug

Answer 6

Sensitization

Question 7

Evidence of physical dependence; adaptive changes that are apparent once drug exposure is terminated

Answer 7

Withdrawal

Question 8

Describe the Schedule levels for Controlled Substances

Answer 8

1 = no medical use; high addiction potential
2/3/4 = medical use; high to low abuse potential

Question 9

What type of drugs are methamphetamine and cocaine?

Answer 9

Stimulants

Question 10

What can Methamphetamine treat?

Answer 10

Obesity

ADHD

Question 11

What are the symptoms of Methamphetamine?

Answer 11

Agitation
Paranoia
Anxiety

Question 12

MOA for Cocaine?

Answer 12

(-) dopamine reuptake

Question 13

What drug (-) dopamine reuptake?

Answer 13

Cocaine

Question 14

What are the symptoms of Cocaine?

Answer 14

Euphoria
Increased alertness
Anxiety/Irritability

Question 15

High doses or prolonged use of Cocaine can cause what?

Answer 15

Paranoia

Question 16

With Cocaine, tolerance develops ____

Answer 16

Rapidly

– take higher and higher doses

Question 17

With Cocaine, what follows the Euphoria?

Answer 17

Crash

= Exhaustion, sleep, depression

Question 18

What are the symptoms of Ketamine?

Answer 18

Dissociative sensations
Hallucinations
Sedation state/amnesia/analgesia/immobility

Question 19

What types of drugs are Ketamine and LSD?

Answer 19

Hallucinogens

Question 20

If a person is in an unresponsive state with uncontrolled eye movements, muscle stiffening, dilated pupils and salivation, what drug are they likely on?

Answer 20

Ketamine

Question 21

As Ketamine wears off, what are the 3 symptoms?

Answer 21

Agitation
Confusion
Hallucinations

Question 22

As Ketamine wears off, what are they 3 symptoms?

Answer 22

Agitation
Confusion
Hallucinations

Question 23

What are the symptoms of LSD (lysergic acid diethylamine)?

Answer 23

Vision, mood changes

Distortion of world and time around you

Question 24

What is a dangerous adverse effect that can occur with LSD?

Answer 24

Can produce flashbacks months/years after taking last dose!

Question 25

What drug can produce flashbacks months/years after taking last dose?

Answer 25

LSD (lysergic acid diethylamide)

Question 26

Overdose effects of barbiturates, benzodiazepines, ethanol produce what types of behavior?

Answer 26

Drunken behavior

Question 27

What are the withdrawal effects of barbiturates, benzodiazepines and ethanol?

Answer 27

Anxiety, insomnia, delirium

Question 28

Overdose effects of Heroin and opioids?

Answer 28

Drowsy and coma

Question 29

What are the withdrawal effects of Heroin and opioids?

Answer 29

N/V, chills, cramps, lacrimation, yawning, hyperpnea

Question 30

What is a long term effect of PCP?

Answer 30

Irreversible schizophrenia-like psychosis

Question 31

Are Ketamine, LSD and PCP addictive?

Answer 31

NO | -- just can have long term effects

Question 32

Caffeine increases mental alertness. If you combine it with what 2 things, what will it treat?

Answer 32

Caffeine + analgesics + ergotamine = treats migraine headaches

Question 33

There are tons of clinical uses for Caffeine. List a few.

Answer 33

Weight loss Type 2 DM Breathing issues

Question 34

High doses of Caffeine + Ephedrine =

Answer 34

Alternative to illegal stimulants

Question 35

1 alcoholic drink takes how long to metabolize?

Answer 35

1 hour

Question 36

1 alcoholic drink takes how long to metabolize?

Answer 36

1 hour

Question 37

Binge drinking limits for women and men (on one occasion)

Answer 37

Women: > 4 drinks Men: > 5 drinks

Question 38

Heavy drinking limits for women and men?

Answer 38

Women: > 8 drinks/week Men: > 15 drinks/week

Question 39

What type of kinetics does Alcohol metabolism follow?

Answer 39

Zero-order | = Rate is CONSTANT and independent of amount

Question 40

What type of kinetics does Alcohol metabolism follow?

Answer 40

Zero-order | = Rate is CONSTANT and independent of amount

Question 41

What is the rate limiting factor for Alcohol metabolism and its half life increases with?

Answer 41

Biological system = rate limiting factor | -- half life increases with dose

Question 42

Describe the cascade of Alcohol Metabolism

Answer 42

- Alcohol - Acetaldehyde - Acetate

Question 43

What enzyme takes Alcohol to Acetaldehyde?

Answer 43

Alcohol Dehydrogenase

Question 44

What enzyme takes Acetaldehyde to Acetate?

Answer 44

Acetaldehyde Dehydrogenase

Question 45

MOA for Disulfiram?

Answer 45

(-) Acetaldehyde Dehydrogenase | ==> build up of Acetaldehyde

Question 46

What is the result of Disulfiram?

Answer 46

Discomfort while drinking alcohol due to the buildup of Acetaldehyde = Flushing, N/V, sweating, headache

Question 47

MOA for Acamprosate?

Answer 47

NMDA antagonist and GABAa agonist

Question 48

What is the result of taking Acamprosate?

Answer 48

Decreased desire to drink alcohol and relapse rates

Question 49

There is extensive first pass metabolism of Alcohol with what enzyme?

Answer 49

Alcohol Dehydrogenase

Question 50

What drug can (-) Alcohol Dehydrogenase and treat methanol/ethylene glycol poisoning?

Answer 50

Fomepizole