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NMSP - Exam 3 > 1st Generation Antipsychotics > Flashcards

1st Generation Antipsychotics Flashcards

1
Q

There are 10 1st generation agents. 5 of them end in what suffix?

A
  • azine
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2
Q

What 5 agents end in -azine?

A 
Chlorpromazine
Fluphenazine
Perphenazine
Thioridazine
Trifluoperazine
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3
Q

What 5 agents do NOT end in -azine?

A 
Haloperidol
Loxapine
Molindone
Pimozide
Thiothixene
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4
Q

What is the MOA for the 1st generation agents?

A

Block Dopamine (D2) post-synaptic receptors

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5
Q

What is the MOA for the 1st generation agents?

A

Block Dopamine (D2) post-synaptic receptors

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6
Q

The 1st generation agents can also block a few other receptors that can result in side effects. What are they?

A
  1. Histamine
  2. Muscarinic
  3. Alpha1 Adrendergic
  4. D2 in the Nigrostriatal pathway and in the Tuberoinfundibular pathway
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7
Q

The 1st generation agents can also block other receptors that lead to side effects. What are those receptors and effects?

A
  1. Histamine –> Sedation
  2. Muscarinic –> Anticholinergic
  3. Alpha1 Adrenergic –> Cardiovascular
  4. D2 in the nigrostriatal pathway –> EPS
  5. D2 in the tuberofundibular pathway –> Prolactin elevation
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8
Q

What are 2 LOW potency agents?

A

Chlorpromazine

Thioridazine

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9
Q

What are 2 LOW potency agents?

A

Chlorpromazine

Thioridazine

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10
Q

What general effects do the LOW potency agents cause?

A

(Chlorpromazine, Thioridazine)

= Sedation, ECG effects and Hypotension

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11
Q

What side effect can Thioridazine cause?

A

Torsade de pointes or cardiac death

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12
Q

What are 2 HIGH potency agents?

A

Fluphenazine

Haloperidol

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13
Q

What are 2 HIGH potency agents?

A

Fluphenazine

Haloperidol

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14
Q

What general effects do the HIGH potency agents cause?

A

(Fluphenazine, Haloperidol)
= More movement and Endocrine effects
==> EPS and Prolactin elevation

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15
Q

What 3 Extrapyramidal Symptoms can be caused by 1st generation agents?

A

Dystonia
Akathisia
Parkinsonism

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16
Q

What 3 Extrapyramidal Symptoms can be caused by 1st generation agents?

A

Dystonia
Akathisia
Parkinsonism

17
Q

What are the symptoms of Dystonia?

A

Sustained muscle contractions

18
Q

If Dystonia occurs within a few hours/days, what are the antidotes?

A

Anticholinergics

= Benztropine, Diphenhydramine, Trihexyphenidyl

19
Q

If Dystonia occurs within a few hours/days, what are the antidotes?

A

Anticholinergics

= Benztropine, Diphenhydramine, Trihexyphenidyl

20
Q

What are the symptoms of Akathisia?

A

CONSTANT movements – cannot stay still

21
Q

If Akathisia occurs within a few days/weeks, what are the antidotes?

A

3 B’s

= Beta blocker (propranolol), Benzodiazepine (lorazepam), Benztropine

22
Q

If Akathisia occurs within a few days/weeks, what are the antidotes?

A

3 B’s

= Beta blocker (propranolol), Benzodiazepine (lorazepam), Benztropine

23
Q

What are the symptoms of Parkinsonism?

A

Bradykinesia
Tremor
Rigidity

24
Q

If Parkinsonism occurs in weeks/months, what are the antidotes?

A

Benztropine (Anticholinergic)

Amantadine (Dopamine enhancer)

25
Q

If Parkinsonism occurs in weeks/months, what are the antidotes?

A

Benztropine (Anticholinergic)

Amantadine (Dopamine enhancer)

26
Q

Besides Extrapyramidal Symptoms, what other movement disorder can occur with the use of 1st generation agents?

A

Tardive Dyskinesia

27
Q

What are the signs of Tardive Dyskinesia?

A

Repetitive uncontrollable movements

28
Q

Repetitive uncontrollable movements with the use of 1st generation agents?

A

Tardive Dyskinesia

29
Q

If Tardive Dyskinesia occurs, what are the antidotes and their MOA?

A

VMAT2 (-)’s

- end in BENAZINE

30
Q

If Tardive Dyskinesia occurs, what are the antidotes and their MOA?

A

VMAT2 (-)’s

- end in BENAZINE

31
Q

If a drug is given with the BENAZINE suffix, what is it treating?

A

Tardive Dyskinesia

32
Q

What endocrine adverse effect can occur with the use of 1st generation agents?

A

Hyperprolactinemia

33
Q

If Hyperprolactinemia occurs, what are the signs?

A

Amenorrhea
Galactorrhea
Gynecomastia

34
Q

Fluphenazine and Haloperidol are ___ potency agents

A

HIGH

35
Q

Chlorpromazine and Thioridazine are ___ potency agents

A

LOW

36
Q

What are the 5 agents that end in -azine?

A 
Chlorpromazine
Fluphenazine
Perphenazine
Thioridazine
Trifluoperazine
37
Q

What are the 5 agents that end in -azine?

A 
Chlorpromazine
Fluphenazine
Perphenazine
Thioridazine
Trifluoperazine
38
Q

What are the 5 agents that do NOT end in -azine?

A 
Haloperidol
Loxapine
Molindone
Pimozide
Thiothixene
39
Q

What are the 5 agents that do NOT end in -azine?

A 
Haloperidol
Loxapine
Molindone
Pimozide
Thiothixene

NMSP - Exam 3 (22 decks)

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