SNRIs Flashcards
What are all the SNRIs?
**All TCAs Duloxetine Venlafaxine Desvenlafaxine Levomilnacipran
What are all the SNRIs?
**All TCAs Duloxetine Venlafaxine Desvenlafaxine Levomilnacipran
What SNRI is only for Fibromyalgia?
Milnacipran
Milnaciprain is ONLY for what condition?
Fibromyalgia
What are the 5 Tertiary Amines (TCAs)?
Amitriptyline Doxepin Imipramine Trimipramine Clomipramine
What are the 5 Tertiary Amines (TCAs)?
Amitriptyline Doxepin Imipramine Trimipramine Clomipramine
What are the 5 Tertiary Amines (TCAs)?
Amitriptyline Doxepin Imipramine Trimipramine Clomipramine
What are the 4 Secondary Amines (TCAs)?
Nortriptyline
Protriptyline
Amoxapine
Desipramine
What are the 4 Secondary Amines (TCAs)?
Nortriptyline
Protriptyline
Amoxapine
Desipramine
What are the 4 Secondary Amines (TCAs)?
Nortriptyline
Protriptyline
Amoxapine
Desipramine
Which SNRI has an extra MOA and what is it?
Amoxapine
= Dopamine ANTAGONIST
What are Amoxapines MOA?
SNRI (secondary amine TCA)
D2 dopamine ANTAGONIST
Which SNRI can treat Enuresis?
Imipramine
What specific condition can Imipramine be used for?
Enuresis (bed wetting)
Which SNRI can also treat diabetic peripheral neuropathy, fibromyalgia, MSK pain and stress incontinence?
Duloxetine
TCAs can BLOCK other receptors. What are those 3 receptors?
- Histamine
- Muscarinic
- Alpha Adrenergic
TCAs can BLOCK other receptors. What are those 3 receptors?
- Histamine
- Muscarinic
- Alpha Adrenergic
TCAs block 3 other receptors. What are they and what side effects do they result in?
- Histamine –> CNS
- Muscarinic –> Anticholinergic
- Alpha Adrenergic –> Cardiovascular
What are the 3 symptoms of TCA overdose?
Coma
Conduction abnormalities
Convulsions
What are the 3 symptoms of TCA overdose?
Coma
Conduction abnormalities
Convulsions
SNRIs have ___ sexual dysfunction than SSRIs
LESS
What are 3 general side effects from SNRIs?
Agitation
Insomnia
HTN
What are 3 general side effects of SNRIs?
Agitation
Insomnia
HTN
If a person has a slowed heart conduction from Na+ channel blockade, what did they likely do?
TCA overdose
What is the MOA for SNRIs?
Serotonin Norepinephrine Reuptake Inhibitors
= (-) pre-synaptic reuptake of serotonin via SERT and norepinephrine via NET