Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

NMSP - Exam 3 > Sedative and Hypnotic Drugs > Flashcards

Sedative and Hypnotic Drugs Flashcards

1
Q

What are 3 Barbiturates?

A

Phenobarbital
Pentobarbital
Thiopental

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is a Melatonin Agonist?

A

Ramelteon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is a Melatonin Agonist?

A

Ramelteon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is an Antihistamine?

A

Doxepin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is an Antihistamine?

A

Doxepin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is a Dual Orexin Receptor Antagonist?

A

Suvorexant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is a Dual Orexin Receptor Antagonist?

A

Suvorexant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are 2 Non-Benzodiazepine (BZ1) Agonists?

A

Eszopiclone

Zolpidem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are 2 Non-Benzodiazepine (BZ1) Agonists?

A

Eszopiclone

Zolpidem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is a Benzodiazepine Antagonist?

A

Flumazenil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is a Benzodiazepine Antagonist?

A

Flumazenil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Producing relaxation, calmness and decreased motor activity WITHOUT LOSS OF CONSCIOUSNESS

A

Sedation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Inducing drowsiness, decreased motor and sensory activity with DEPRESSED STATE OF CONSCIOUSNESS

A

Hypnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

With the GABA-A Receptor, GABA binds and causes what ion to enter the cell? What is the result?

A

Cl- enters the cell

=> Hyperpolarizes cell membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What 3 classes of drugs act on the GABA-A receptor?

A

Benzodiazepines
Barbiturates
BZ1 Selectives

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Both Benzodiazepines and Barbiturates are addictive. Which is the more addictive and dangerous?

A

Barbiturates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are the 2 low potency Benzodiazepines?

A

Diazepam

Temazepam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which low potency Benzodiazepine has a long half life?

A

Diazepam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are 4 high potency Benzodiazepines?

A

Clonazepam
Alprazolam
Lorazepam
Triazolam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Which high potency Benzodiazepine has a long half life?

A

Clonazepam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Short half life Benzodiazepines may cause?

A

Amnesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is a common side effect of Benzodiazepines?

A

Drowsiness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Which 3 Benzodiazepines are often used for anxiety?

A

Alprazolam
Clonazepam
Lorazepam

24
Q

Alprazolam, Clonazepam, Lorazepam can all be used for?

A

Anxiety

25
Q

Which 2 Benzodiazepines are often used for Insomnia?

A

Temazepam

Triazolam

26
Q

Temazepam and Triazolam are often used for?

A

Insomnia

27
Q

What is Midazolam often used for and what is a possible IV adverse effect?

A

Induction of Anesthesia

=> Respiratory depression/arrest may occur

28
Q

If you combine Benzodiazepines with Opioids, what possible adverse effects?

A

Sedation
Respiratory depression
Coma
Death

29
Q

What are the Non-Benzodiazepine (BZ1) Agonists used for?

A

Insomnia

30
Q

How can Zolpidem be given?

A

Sublingual tablets

Oral spray

31
Q

Which Non-Benzodiazepine (BZ1) Agonist has a longer half life?

A

Eszopiclone

32
Q

What are the possible adverse effects of Zolpidem/Eszopiclone?

A

Complex sleep behaviors: walking, driving and other activities while asleep

33
Q

What is the MOA of Flumazenil?

A

Antagonist at Benzodiazepine binding sites on GABA-A receptor to block actions of Benzodiazepines

34
Q

When is Flumazenil used?

A

Reversal of Benzodiazepine induced sedation or overdose

35
Q

What is a possible adverse effect of Flumazenil?

A

Seizures especially if on long term sedation or TCAs

36
Q

At high doses, what drug class can open the Cl- channel withOUT GABA?

A

Barbiturates

37
Q

What Barbiturate has the longest half life and can control tonic clonic seizures?

A

Phenobarbital

38
Q

What drug interactions do Barbiturates have?

A

CYP3A4 INDUCERS

39
Q

What are possible adverse effects of Barbiturates?

A

Addictive
Respiratory Depression
Sneeze, cough, laryngospasm

40
Q

What Barbiturate has the shortest half life?

A

Thiopental

41
Q

What is the MOA for Buspirone?

A

Unknown; partial agonist at 5-HT receptors

42
Q

Which drug has an unknown MOA but is a partial agonist at 5-HT?

A

Buspirone

43
Q

What is Buspirone used for?

A

Anxiety and partial antidepressant

44
Q

What is good about Buspirone?

A

Lacks tolerance, dependence, withdrawal, sedation/hypnotic effects

45
Q

What are 3 possible side effects of Buspirone?

A

Insomnia
Agitation
Nausea

46
Q

What is the MOA for Ramelteon?

A

Melatonin Agonist at MT1 and MT2 receptors

47
Q

What can Ramelteon treat?

A

Sleep disorders

– rapid onset of sleep

48
Q

What (-) the pineal release of Melatonin?

A

Sunlight

49
Q

What is the MOA for Suvorexant?

A

Blocks binding of Orexins that promote wakefulness

==> Promotes sleep

50
Q

What drug can block binding of Orexins that promote wakefulness in order to treat insomnia?

A

Suvorexant

dual orexin receptor antagonist

51
Q

What are possible adverse effects of Suvorexant?

A

Next day somnolence and driving impairment

Complex-sleep behaviors

52
Q

What is the MOA for Doxepin?

A 
Antagonizes H1 (histamine) receptors
-- (-) reuptake of NE and 5-HT
53
Q

What can Doxepin treat?

A

Insomnia – causes sedation

54
Q

What are 2 adverse effects of Doxepin?

A

Suicidal ideation

Anticholinergic effects

55
Q

What drugs can treat Insomnia? (7)

A 
Doxepin
Suvorexant
Ramelteon
Zolpidem
Eszopiclone
Temazepam
Triazolam

NMSP - Exam 3 (22 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions