SSRIs Flashcards
What are the 5 R’s of Antidepressant Efficacy?
- Response
- Remission
- Relapse
- Recovery
- Recurrence
What are the 5 R’s of Antidepressant Efficacy and their definitions?
- Response = > 50% reduction in symptoms
- Remission = Symptom free
- Relapse = Return of symptoms after remission/before recovery
- Recovery = 6-12 months of Symptom free
- Recurrence = Return of symptoms after recovery
What are the 7 SSRIs?
Citalopram Escitalopram Fluoxetine Paroxetine Sertraline Vilazodone Vortioxetine
What are the 7 SSRIs?
Citalopram Escitalopram Fluoxetine Paroxetine Sertraline Vilazodone Vortioxetine
What are the 2 SSRIs that have an extra MOA?
Vilazodone
Vortioxetine
What SSRI can be used for OCD ONLY?
Fluvoxamine
Fluvoxamine is used for only what?
OCD
MOA for SSRIs?
Serotonin Selective Reuptake Inhibitor
= (-) pre-synaptic reuptake of Serotonin via SERT
Which SSRI has the most drug-drug interactions?
Fluoxetine
Which SSRI has the longest half life?
Fluoxetine
What is a side effect of Paroxetine that you should watch the elderly for?
Anticholinergic
Which SSRi is a 2D6 inhibitor and category D for pregnancy risk?
Paroxetine
Which SSRI has the shortest half life?
Sertraline
What are 4 side effects of SSRIs?
Weight gain
Sexual dysfunction
QT prolongation
Hyponatremia
What are 4 side effects of SSRIs?
Weight gain
Sexual dysfunction
QT prolongation
Hyponatremia
What is a very serious adverse effect that can occur with SSRIs especially when taken with other serotonin affecting agents?
Serotonin Syndrome
ALL Antidepressants can cause Withdrawal Syndrome. What are the effects of that?
FINISH
- Flu-like
- Insomnia
- Nausea
- Imbalance
- Sensory disturbances
- Hyperarousal
ALL Antidepressants can cause Withdrawal Syndrome. What are the effects of that?
FINISH
- Flu-like
- Insomnia
- Nausea
- Imbalance
- Sensory disturbances
- Hyperarousal
How should you stop taking ALL antidepressants?
Slow titration downward
ALL Antidepressants can increase _______
INCREASE Suicidal Ideations
ALL Antidepressants can increase suicidal ideations, especially in what age group?
Younger adults/kids
– < 24 years old
Which SSRI has the most drug interactions and longest half life?
Fluoxetine
What are the 7 SSRIs?
Citalopram Escitalopram Fluoxetine Paroxetine Sertraline Vilazodone Vortioxetine
What are the MOAs for Vilazodone?
SSRI - (-) serotonin reuptake via SERT
5-HT partial AGONIST
What are the MOAs for Vortioxetine?
SSRI - (-) serotonin reuptake via SERT
5-HT partial and full agonist/antagonist
