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NMSP - Exam 3 > SSRIs > Flashcards

SSRIs Flashcards

1
Q

What are the 5 R’s of Antidepressant Efficacy?

A
  1. Response
  2. Remission
  3. Relapse
  4. Recovery
  5. Recurrence
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2
Q

What are the 5 R’s of Antidepressant Efficacy and their definitions?

A
  1. Response = > 50% reduction in symptoms
  2. Remission = Symptom free
  3. Relapse = Return of symptoms after remission/before recovery
  4. Recovery = 6-12 months of Symptom free
  5. Recurrence = Return of symptoms after recovery
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3
Q

What are the 7 SSRIs?

A 
Citalopram
Escitalopram
Fluoxetine
Paroxetine
Sertraline
Vilazodone
Vortioxetine
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4
Q

What are the 7 SSRIs?

A 
Citalopram
Escitalopram
Fluoxetine
Paroxetine
Sertraline
Vilazodone
Vortioxetine
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5
Q

What are the 2 SSRIs that have an extra MOA?

A

Vilazodone

Vortioxetine

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6
Q

What SSRI can be used for OCD ONLY?

A

Fluvoxamine

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7
Q

Fluvoxamine is used for only what?

A

OCD

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8
Q

MOA for SSRIs?

A

Serotonin Selective Reuptake Inhibitor

= (-) pre-synaptic reuptake of Serotonin via SERT

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9
Q

Which SSRI has the most drug-drug interactions?

A

Fluoxetine

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10
Q

Which SSRI has the longest half life?

A

Fluoxetine

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11
Q

What is a side effect of Paroxetine that you should watch the elderly for?

A

Anticholinergic

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12
Q

Which SSRi is a 2D6 inhibitor and category D for pregnancy risk?

A

Paroxetine

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13
Q

Which SSRI has the shortest half life?

A

Sertraline

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14
Q

What are 4 side effects of SSRIs?

A

Weight gain
Sexual dysfunction
QT prolongation
Hyponatremia

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15
Q

What are 4 side effects of SSRIs?

A

Weight gain
Sexual dysfunction
QT prolongation
Hyponatremia

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16
Q

What is a very serious adverse effect that can occur with SSRIs especially when taken with other serotonin affecting agents?

A

Serotonin Syndrome

17
Q

ALL Antidepressants can cause Withdrawal Syndrome. What are the effects of that?

A

FINISH

  • Flu-like
  • Insomnia
  • Nausea
  • Imbalance
  • Sensory disturbances
  • Hyperarousal
18
Q

ALL Antidepressants can cause Withdrawal Syndrome. What are the effects of that?

A

FINISH

  • Flu-like
  • Insomnia
  • Nausea
  • Imbalance
  • Sensory disturbances
  • Hyperarousal
19
Q

How should you stop taking ALL antidepressants?

A

Slow titration downward

20
Q

ALL Antidepressants can increase _______

A

INCREASE Suicidal Ideations

21
Q

ALL Antidepressants can increase suicidal ideations, especially in what age group?

A

Younger adults/kids

– < 24 years old

22
Q

Which SSRI has the most drug interactions and longest half life?

A

Fluoxetine

23
Q

What are the 7 SSRIs?

A 
Citalopram
Escitalopram
Fluoxetine
Paroxetine
Sertraline
Vilazodone
Vortioxetine
24
Q

What are the MOAs for Vilazodone?

A

SSRI - (-) serotonin reuptake via SERT

5-HT partial AGONIST

25
Q

What are the MOAs for Vortioxetine?

A

SSRI - (-) serotonin reuptake via SERT

5-HT partial and full agonist/antagonist

NMSP - Exam 3 (22 decks)

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