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NMSP - Exam 3 > Mood Stabilizers > Flashcards

Mood Stabilizers Flashcards

1
Q

What are the 4 mood stabilizers?

A

Lithium
Valproic Acid
Carbamazepine
Lamotrigine

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2
Q

What are the 4 mood stabilizers?

A

Lithium
Valproic Acid
Carbamazepine
Lamotrigine

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3
Q

What are the 3 Anti-Seizure Agents that can be used as mood stabilizers?

A

Valproic Acid
Carbamazepine
Lamotrigine

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4
Q

What is another name for a Valproic Acid similar?

A

Divalproex

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5
Q

Divalproex is similar to?

A

Valproic Acid

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6
Q

What type of ion is Lithium?

A

Monovalent ion (Li+)

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7
Q

What are 3 Neurotransmitter Modulation MOA for Lithium?

A
  1. (-) dopamine neurotransmissioin
  2. (+) GABAergic neurotransmission
  3. (-) NMDA receptor
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8
Q

What are 3 Neurotransmitter Modulation MOAs for Lithium?

A
  1. (-) dopamine neurotransmission
  2. (+) GABAergic neurotransmission
  3. (-) NMDA receptor
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9
Q

Which G proteins does Lithium act on to keep in the inactive state to stop dopamine neurotransmission?

A

Gs and Gi

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10
Q

What are 3 Intracellular changes that Lithium does?

A
  1. Decreases Myoinositol
  2. (-) PKC, MARCKS, GSK-3
  3. (+) CREB
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11
Q

What are 3 Intracellular changes that Lithium does?

A
  1. Decreases Myoinositol
  2. (-) PKC, MARCKS, GSK-3
  3. (+) CREB
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12
Q

How does Lithium decrease Myoinositol?

A

(-) IPPase and IMPase

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13
Q

Once Lithium (+) CREB, what does that cause to be produced?

A

Neuroprotective factors: BDNF and Bcl-2

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14
Q

Lithium competes with what ions in the kidney?

A

Na+ and K+

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15
Q

When Lithium competes with Na+ in the kidney, what can occur?

A

ADH resistance

=> polyuria and polydipsia

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16
Q

When Lithium competes with Na+ in the kidney for reabsorption, what can occur?

A

ADH resistance

=> polyuria and polydipsia

17
Q

What 3 drug classes can Lithium interact with because they also impact Na+/K+?

A

Diuretics
ACEi
NSAIDs

18
Q

Which mood stabilizer is a very narrow therapeutic agent?

A

Lithium

19
Q

What are the indications for use of Lithium?

A

Acute and Maintenance of mania/bipolar 1

20
Q

Which agent works by decreasing Myoinositol, PKC, GSK-3 and MARCKS activity?

A

Valproic Acid/Divalproex

21
Q

What are the side effects of using Valproic Acid?

A

Decreased platelets
Pancreatitis
Increased ammonia

22
Q

What are the indications for Valproic Acid/Divalproex?

A

Acute and Maintenance of mania/biopolar 1

23
Q

Which agent works by decreasing Myoinositol?

A

Carbamazepine

24
Q

What are the side effects of Carbamazepine?

A

Decreased WBC

Decreased Ca+/vit. D –> osteoporosis

25
Q

What are the indications for Carbamazepine?

A

Acute and Maintenance of mania/bipolar 1

26
Q

Which agent works by (-) NMDA, decreasing GSK-3, increasing BDNF, and is a 5HT agonist?

A

Lamotrigine

27
Q

What are the side effects of Lamotrigine?

A

CNS and cardiac

28
Q

What are the indications for Lamotrigine?

A

MAINTENANCE of bipolar 1 only

29
Q

Which mood stabilizer is only used for the maintenance of bipolar 1?

A

Lamotrigine

30
Q

Which mood stabilizers can be used in the acute setting and for maintenance of mania/bipolar 1?

A

Lithium
Valproic Acid
Carbamazepine

NMSP - Exam 3 (22 decks)

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