Mood Stabilizers Flashcards
What are the 4 mood stabilizers?
Lithium
Valproic Acid
Carbamazepine
Lamotrigine
What are the 4 mood stabilizers?
Lithium
Valproic Acid
Carbamazepine
Lamotrigine
What are the 3 Anti-Seizure Agents that can be used as mood stabilizers?
Valproic Acid
Carbamazepine
Lamotrigine
What is another name for a Valproic Acid similar?
Divalproex
Divalproex is similar to?
Valproic Acid
What type of ion is Lithium?
Monovalent ion (Li+)
What are 3 Neurotransmitter Modulation MOA for Lithium?
- (-) dopamine neurotransmissioin
- (+) GABAergic neurotransmission
- (-) NMDA receptor
What are 3 Neurotransmitter Modulation MOAs for Lithium?
- (-) dopamine neurotransmission
- (+) GABAergic neurotransmission
- (-) NMDA receptor
Which G proteins does Lithium act on to keep in the inactive state to stop dopamine neurotransmission?
Gs and Gi
What are 3 Intracellular changes that Lithium does?
- Decreases Myoinositol
- (-) PKC, MARCKS, GSK-3
- (+) CREB
What are 3 Intracellular changes that Lithium does?
- Decreases Myoinositol
- (-) PKC, MARCKS, GSK-3
- (+) CREB
How does Lithium decrease Myoinositol?
(-) IPPase and IMPase
Once Lithium (+) CREB, what does that cause to be produced?
Neuroprotective factors: BDNF and Bcl-2
Lithium competes with what ions in the kidney?
Na+ and K+
When Lithium competes with Na+ in the kidney, what can occur?
ADH resistance
=> polyuria and polydipsia
When Lithium competes with Na+ in the kidney for reabsorption, what can occur?
ADH resistance
=> polyuria and polydipsia
What 3 drug classes can Lithium interact with because they also impact Na+/K+?
Diuretics
ACEi
NSAIDs
Which mood stabilizer is a very narrow therapeutic agent?
Lithium
What are the indications for use of Lithium?
Acute and Maintenance of mania/bipolar 1
Which agent works by decreasing Myoinositol, PKC, GSK-3 and MARCKS activity?
Valproic Acid/Divalproex
What are the side effects of using Valproic Acid?
Decreased platelets
Pancreatitis
Increased ammonia
What are the indications for Valproic Acid/Divalproex?
Acute and Maintenance of mania/biopolar 1
Which agent works by decreasing Myoinositol?
Carbamazepine
What are the side effects of Carbamazepine?
Decreased WBC
Decreased Ca+/vit. D –> osteoporosis
What are the indications for Carbamazepine?
Acute and Maintenance of mania/bipolar 1
Which agent works by (-) NMDA, decreasing GSK-3, increasing BDNF, and is a 5HT agonist?
Lamotrigine
What are the side effects of Lamotrigine?
CNS and cardiac
What are the indications for Lamotrigine?
MAINTENANCE of bipolar 1 only
Which mood stabilizer is only used for the maintenance of bipolar 1?
Lamotrigine
Which mood stabilizers can be used in the acute setting and for maintenance of mania/bipolar 1?
Lithium
Valproic Acid
Carbamazepine
