Anti-Depressants Cont.

Question 1

What does SARA stand for?

Answer 1

Serotonin Adrenergic Receptor Antagonists

Question 2

What are the 3 SARAs?

Answer 2

Nefazodone
Trazodone
Mirtazapine

Question 3

What are the 3 SARAs?

Answer 3

Nefazodone
Trazodone
Mirtazapine

Question 4

What are the 2 SARAs that block post-synaptic alpha1 adrenergic receptors and 5HT receptors?

Answer 4

Nefazodone

Trazodone

Question 5

What SARA blocks pre-synaptic alpha2 adrenergic receptors and post-synaptic 5HT receptors?

Answer 5

Mirtazapine

Question 6

What is a side effect of Nefazodone?

Answer 6

Hepatotoxic

Question 7

What are 2 side effects of Trazodone?

Answer 7

Sedation

Orthostatic Hypotension

Question 8

What are 2 side effects of Mirtazapine?

Answer 8

Sedation

Weight gaini

Question 9

What does NDRI stand for?

Answer 9

Norepinephrine Dopamine Reuptake Inhibitor

Question 10

What is 1 NDRI?

Answer 10

Bupropion

Question 11

What is 1 NDRI?

Answer 11

Bupropion

Question 12

What is the MOA for Bupropion?

Answer 12

NDRI

= (-) pre-synaptic reuptake of norepinephrine via NET and dopamine via DAT

Question 13

Besides being an NDRI, what else can Bupropion do?

Answer 13

Enhance release of norepinephrine and dopamine via VMAT2

Question 14

What drug can also enhance release of NE and DA via VMAT2?

Answer 14

Bupropion

Question 15

What are 3 possible adverse effects of Bupropion?

Answer 15

Seizures
Agitation
Weight loss

Question 16

What are 3 possible adverse effects of Bupropion?

Answer 16

Seizures
Agitation
Weight loss

Question 17

What is the MOA for MAOIs?

Answer 17

(-) Monoamine Oxidase –> Increasing Monoamines –> Increased release of NE/5HT/DA

Question 18

What are the 4 MAOIs?

Answer 18

Isocarboxazid
Phenelzine
Selegiline
Tranylcypromine

Question 19

What are the 4 MAOIs?

Answer 19

Isocarboxazid
Phenelzine
Selegiline
Tranylcypromine

Question 20

What are the 4 MAOIs?

Answer 20

Isocarboxazid
Phenelzine
Selegiline
Tranylcypromine

Question 21

All of the MAO inhibitors are non-selective except for?

Answer 21

Selegiline

Question 22

Unique Selegiline attributes?

Answer 22

MAO-B selective!!

- Worn as a patch for depression

Question 23

What is an adverse effect of Phenelzine?

Answer 23

Sedation

Question 24

Which MAOI is selective for MAO-B?

Answer 24

Selegiline

Question 25

What is a serious adverse effect that can occur with MAOIs?

Answer 25

Risk of Hypertensive Crisis

Question 26

What is a serious adverse effect that can occur with MAOIs?

Answer 26

Risk of Hypertensive Crisis

Question 27

How does a Hypertensive Crisis arise with MAOIs?

Answer 27

(-) MAO-A in the GI tract - -> DECREASED Tyramine metabolism - -> INCREASED Catecholamines

Question 28

How does a Hypertensive Crisis arise with MAOIs?

Answer 28

(-) MAO-A in GI tract - -> Decreased Tyramine metabolism (builds up) - -> Increased Catecholamine release

Question 29

How may a Hypertensive Crisis be activated with MAOIs?

Answer 29

Eating foods/drinks high in Tyramine

Question 30

What are 2 Misc. Agents?

Answer 30

Esketamine | Brexanolone

Question 31

What are 2 Misc. Agents?

Answer 31

Esketamine | Brexanolone

Question 32

What is the MOA for Esketamine?

Answer 32

NMDA Antagonist

Question 33

When is Esketamine used?

Answer 33

Treatment resistant depression and MDD with suicidal ideation

Question 34

Which agent is given via nasal route and must be observed for 2 hours?

Answer 34

Esketamine

Question 35

What is the MOA for Brexanolone?

Answer 35

GABA(a) Receptor Positive Allosteric Modulator | -- enhances GABA response

Question 36

When is Brexanolone used?

Answer 36

Post-partum depression

Question 37

Which agent is given via IV for 60 hours with efficacy that lasts up to 30 days?

Answer 37

Brexanolone

Question 38

Which agent is used for post-partum depression and is identical to allopregnanolone?

Answer 38

Brexanolone

Question 39

Which agent is used for treatment resistant depression and MDD with suicidal ideation?

Answer 39

Esketamine

Question 40

What specific condition can Bupropion be used for?

Answer 40

Nicotine withdrawal