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NMSP - Exam 3 > Anti-Depressants Cont. > Flashcards

Anti-Depressants Cont. Flashcards

1
Q

What does SARA stand for?

A

Serotonin Adrenergic Receptor Antagonists

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2
Q

What are the 3 SARAs?

A

Nefazodone
Trazodone
Mirtazapine

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3
Q

What are the 3 SARAs?

A

Nefazodone
Trazodone
Mirtazapine

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4
Q

What are the 2 SARAs that block post-synaptic alpha1 adrenergic receptors and 5HT receptors?

A

Nefazodone

Trazodone

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5
Q

What SARA blocks pre-synaptic alpha2 adrenergic receptors and post-synaptic 5HT receptors?

A

Mirtazapine

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6
Q

What is a side effect of Nefazodone?

A

Hepatotoxic

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7
Q

What are 2 side effects of Trazodone?

A

Sedation

Orthostatic Hypotension

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8
Q

What are 2 side effects of Mirtazapine?

A

Sedation

Weight gaini

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9
Q

What does NDRI stand for?

A

Norepinephrine Dopamine Reuptake Inhibitor

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10
Q

What is 1 NDRI?

A

Bupropion

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11
Q

What is 1 NDRI?

A

Bupropion

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12
Q

What is the MOA for Bupropion?

A

NDRI

= (-) pre-synaptic reuptake of norepinephrine via NET and dopamine via DAT

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13
Q

Besides being an NDRI, what else can Bupropion do?

A

Enhance release of norepinephrine and dopamine via VMAT2

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14
Q

What drug can also enhance release of NE and DA via VMAT2?

A

Bupropion

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15
Q

What are 3 possible adverse effects of Bupropion?

A

Seizures
Agitation
Weight loss

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16
Q

What are 3 possible adverse effects of Bupropion?

A

Seizures
Agitation
Weight loss

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17
Q

What is the MOA for MAOIs?

A

(-) Monoamine Oxidase –> Increasing Monoamines –> Increased release of NE/5HT/DA

18
Q

What are the 4 MAOIs?

A

Isocarboxazid
Phenelzine
Selegiline
Tranylcypromine

19
Q

What are the 4 MAOIs?

A

Isocarboxazid
Phenelzine
Selegiline
Tranylcypromine

20
Q

What are the 4 MAOIs?

A

Isocarboxazid
Phenelzine
Selegiline
Tranylcypromine

21
Q

All of the MAO inhibitors are non-selective except for?

A

Selegiline

22
Q

Unique Selegiline attributes?

A

MAO-B selective!!

- Worn as a patch for depression

23
Q

What is an adverse effect of Phenelzine?

A

Sedation

24
Q

Which MAOI is selective for MAO-B?

A

Selegiline

25
Q

What is a serious adverse effect that can occur with MAOIs?

A

Risk of Hypertensive Crisis

26
Q

What is a serious adverse effect that can occur with MAOIs?

A

Risk of Hypertensive Crisis

27
Q

How does a Hypertensive Crisis arise with MAOIs?

A

(-) MAO-A in the GI tract

  • -> DECREASED Tyramine metabolism
  • -> INCREASED Catecholamines
28
Q

How does a Hypertensive Crisis arise with MAOIs?

A

(-) MAO-A in GI tract

  • -> Decreased Tyramine metabolism (builds up)
  • -> Increased Catecholamine release
29
Q

How may a Hypertensive Crisis be activated with MAOIs?

A

Eating foods/drinks high in Tyramine

30
Q

What are 2 Misc. Agents?

A

Esketamine

Brexanolone

31
Q

What are 2 Misc. Agents?

A

Esketamine

Brexanolone

32
Q

What is the MOA for Esketamine?

A

NMDA Antagonist

33
Q

When is Esketamine used?

A

Treatment resistant depression and MDD with suicidal ideation

34
Q

Which agent is given via nasal route and must be observed for 2 hours?

A

Esketamine

35
Q

What is the MOA for Brexanolone?

A

GABA(a) Receptor Positive Allosteric Modulator

– enhances GABA response

36
Q

When is Brexanolone used?

A

Post-partum depression

37
Q

Which agent is given via IV for 60 hours with efficacy that lasts up to 30 days?

A

Brexanolone

38
Q

Which agent is used for post-partum depression and is identical to allopregnanolone?

A

Brexanolone

39
Q

Which agent is used for treatment resistant depression and MDD with suicidal ideation?

A

Esketamine

40
Q

What specific condition can Bupropion be used for?

A

Nicotine withdrawal

NMSP - Exam 3 (22 decks)

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