Anti-Depressants Cont. Flashcards
What does SARA stand for?
Serotonin Adrenergic Receptor Antagonists
What are the 3 SARAs?
Nefazodone
Trazodone
Mirtazapine
What are the 3 SARAs?
Nefazodone
Trazodone
Mirtazapine
What are the 2 SARAs that block post-synaptic alpha1 adrenergic receptors and 5HT receptors?
Nefazodone
Trazodone
What SARA blocks pre-synaptic alpha2 adrenergic receptors and post-synaptic 5HT receptors?
Mirtazapine
What is a side effect of Nefazodone?
Hepatotoxic
What are 2 side effects of Trazodone?
Sedation
Orthostatic Hypotension
What are 2 side effects of Mirtazapine?
Sedation
Weight gaini
What does NDRI stand for?
Norepinephrine Dopamine Reuptake Inhibitor
What is 1 NDRI?
Bupropion
What is 1 NDRI?
Bupropion
What is the MOA for Bupropion?
NDRI
= (-) pre-synaptic reuptake of norepinephrine via NET and dopamine via DAT
Besides being an NDRI, what else can Bupropion do?
Enhance release of norepinephrine and dopamine via VMAT2
What drug can also enhance release of NE and DA via VMAT2?
Bupropion
What are 3 possible adverse effects of Bupropion?
Seizures
Agitation
Weight loss
What are 3 possible adverse effects of Bupropion?
Seizures
Agitation
Weight loss
What is the MOA for MAOIs?
(-) Monoamine Oxidase –> Increasing Monoamines –> Increased release of NE/5HT/DA
What are the 4 MAOIs?
Isocarboxazid
Phenelzine
Selegiline
Tranylcypromine
What are the 4 MAOIs?
Isocarboxazid
Phenelzine
Selegiline
Tranylcypromine
What are the 4 MAOIs?
Isocarboxazid
Phenelzine
Selegiline
Tranylcypromine
All of the MAO inhibitors are non-selective except for?
Selegiline
Unique Selegiline attributes?
MAO-B selective!!
- Worn as a patch for depression
What is an adverse effect of Phenelzine?
Sedation
Which MAOI is selective for MAO-B?
Selegiline
What is a serious adverse effect that can occur with MAOIs?
Risk of Hypertensive Crisis
What is a serious adverse effect that can occur with MAOIs?
Risk of Hypertensive Crisis
How does a Hypertensive Crisis arise with MAOIs?
(-) MAO-A in the GI tract
- -> DECREASED Tyramine metabolism
- -> INCREASED Catecholamines
How does a Hypertensive Crisis arise with MAOIs?
(-) MAO-A in GI tract
- -> Decreased Tyramine metabolism (builds up)
- -> Increased Catecholamine release
How may a Hypertensive Crisis be activated with MAOIs?
Eating foods/drinks high in Tyramine
What are 2 Misc. Agents?
Esketamine
Brexanolone
What are 2 Misc. Agents?
Esketamine
Brexanolone
What is the MOA for Esketamine?
NMDA Antagonist
When is Esketamine used?
Treatment resistant depression and MDD with suicidal ideation
Which agent is given via nasal route and must be observed for 2 hours?
Esketamine
What is the MOA for Brexanolone?
GABA(a) Receptor Positive Allosteric Modulator
– enhances GABA response
When is Brexanolone used?
Post-partum depression
Which agent is given via IV for 60 hours with efficacy that lasts up to 30 days?
Brexanolone
Which agent is used for post-partum depression and is identical to allopregnanolone?
Brexanolone
Which agent is used for treatment resistant depression and MDD with suicidal ideation?
Esketamine
What specific condition can Bupropion be used for?
Nicotine withdrawal
