state vet med Flashcards
VM01-10
name the SRUC service
timely detection, investigation and communication of undefined or unexpected threats;
protects access to trade, reduces risk of disease outbreak and environmental impact of animal production, safeguards public health and animal welfare
animal health surveillance
name the two types of animal health surveillance
- scanning/passive
- active/targeted
name the type of animal health surveillance
collation and reporting of data generated from routine clinical diagnostic work
scanning/passive
name the type of animal health surveillanc
pro-active data collection and collation to more accurately describe patterns of disease
active/targeted
name 2 limitations of active surveillance
- must be designed with specific disease threats in mind
- cannot detect new/emerging conditions
name 2 instances where eradication is beneficial
- disease caused by single, identifiable, infectious agent
- agent is teh sole cause of severe animal welfare, production or human health risk
name the programme for preventing foot and mouth disease
- ban rustics and ban trade in cattle
- stable oxen & close all markets
- prohibit treatment & slaughter sick (poleaxe)
- forbid carcase skinning & sale of hides
- forbid sale of diseased meat
- bury whole carcases deeply in lime
- pour milk into deep holes
Lancisi’s Programme
who must be notified by a vet surgeon or farmer if dealing with suspected foot and mouth disease?
APHA or police
what is the temporary control zone for stock standstill around the FMD suspect premises
< 10km
where are samples for suspected FMD cases sent?
inital ELISA result in 4h!
FMD World Reference Laboratory,
Pirbright, Surrey
who was the cause of the primary case of FMD for the 2001 epidemic?
Waugh (pigs)
what market were the 16 infected sheep sold to in 2001, contributing to the 2001 FMD epidemic
mixed with 175 other sheep for 24h
Hexham Market
name 5 reasons we were so far behind in the 2001 FMD epidemic
- delayed notification by primary farm
- 90% pigs affected
- windborne spread
- inapparently affected sheep sold at market
- often few signs of FMD in sheep
what was the average oldest lesion age at report during the 2001 FMD epidemic?
2 days
what was the average incubation period FMD O during the 2001 FMD epidemic?
5 days
name 5 flawed veterinary assumptions that were made for the automatic contiguous cull models during the 2001 FMD epidemic
- ALL animals infected simultaneously
- ALL complete a standard incubation period
- ALL excrete MAXIMALLY 4 days pre-clinically
- ALL animals remain infectious until dead
- radial spread of virus from a farm
name 5 vector-borne transboundary notifiable animal diseases
- Bluetongue
- Lumpy skin disease
- Rift Valley Fever
- African Horse Sickness
- Schmallenberg virus
name the vector-borne transboundary notifiable animal disease
Orbivirus from the Reoviridae family;
27 serotypes;
Hosts: domestic and wild ruminants;
clinical cases in sheep, rest reservoir;
closely related to Epizootic haemorrhagic disease virus
Bluetongue Virus (BTV)
what is the most important way bluetongue virus (BTV) transmitted?
midges genus Culicoides
where does the first replication of bluetongue virus (BTV) take place in the vector?
in midgut cells
where does the second replication of bluetongue virus (BTV) take place in the vector?
salivary glands
where does the first replication of bluetongue virus (BTV) take place in the vertebrate?
regional lymph nodes
where does the second replication of bluetongue virus (BTV) take place in the vertebrate ?
vascular endothelial cells of secondary organs
what 2 things must be done immediately if you have a bluetongue virus (BTV) suspicion?
- isolate the animal
- contact APHA
& don’t leave the farm!!
what is the preferred type of vaccination for bluetongue virus (BTV)?
inactivated vaccines
is there a vaccine for bluetongue virus (BTV)?
YES!!
name the vector-borne transboundary notifiable animal disease?
genus Capripoxivirus, family Poxiviridae;
related to sheep pox and goat pox viruses;
very stable virus;
cattle host, also in buffalo;
survives in environment for long periods
Lumpy Skin Disease Virus (LSDV)
name the 4 arthropod vectors of Lumpy Skin Disease Virus (LSDV)
- mosquitoes
- biting flies: Stomoxys
- Culicoides midges
- Hard ticks
what type of vaccine is available for Lumpy Skin Disease Virus (LSDV)?
live vaccines
can preventative vaccination of Lumpy Skin Disease Virus (LSDV) be used in the UK?
no, prohibited
where can Lumpy Skin Disease Virus (LSDV) vaccination be used?
where disease is endemic
name the vector-borne transboundary notifiable animal disease
Phl;ebovirus, family Phenuiviridae;
ruminants and camels;
high mortality in young animals and abortion storms in adults;
ZOONOTIC - flu-like illness
Rift Valley Fever (RVF) Virus
mosquitoes are a vector for Rift Valley Fever (RVF) Virus and cause what kind of transmission?
transovarian transmission
what post-mortem lesions can be seen with Rift Valley Fever (RVF) Virus?
hepatic necrosis
(and jaundice)
is there a vaccination for Rift Valley Fever (RVF) Virus?
yes
name the vector-borne transboundary animal disease
Orthobunavirus, family Bunyaviridae;
ruminants;
Culicoides;
NOT a notifiable disease - an EMERGING disease
Schmallemberg virus (SBV)
is there a vaccine for Schmallemberg virus (SBV)
yes, not commercially available in UK
name the vector-borne transboundary notifiable animal disease
Orbivirus, family Reoviridae;
9 serotypes;
affects equids (natural reservoir is zebra);
not zoonotic
African Horse Sickness (AHS) virus
what vector is responsible for the transmission of African Horse Sickness (AHS) virus
Culicoides
name the 4 different forms of African Horse Sickness (AHS) virus
- Peracute (pulmonary)
- Subacute oedematous (cardiac)
- acute (mixed)
- horse sickness fever
is vaccination against African Horse Sickness (AHS) virus allowed in the UK?
NO
how long after last African Horse Sickness (AHS) virus vaccination before horses can be moved?
60 days
name the form of African Horse Sickness (AHS) virus
Clinical Signs: acute fever, respiratory distress, forelegs
spread, head extended, and nostrils fully dilated;
Animal often dies within few hours;
Lesions: Interlobular oedema, hydrothorax, fluid present in the trachea and pulmonary airways, haemorrhages
peracute (pulmonary)
name the form of African Horse Sickness (AHS) virus
Clinical Signs: fever, oedematous swellings;
Death from cardiac failure;
Lesions: Hydropericardium, haemorrhages in the epicardium, endocardium and gastrointestinal tract
subacute oedematous (cardiac)
name the form of African Horse Sickness (AHS) virus
Clinical Signs: Mix of pulmonary and cardiac forms;
In most cases, the cardiac form is subclinical and it is
followed by severe respiratory distress;
may be followed by oedema and death from cardiac failure;
Lesions: Interlobular oedema, hydrothorax, fluid present in the trachea and pulmonary airways, haemorrhages
acute (mixed)
name the form of African Horse Sickness (AHS) virus
In resistant species, donkeys and zebras):
Clinical Signs: Fever, morning remissions and afternoon
exacerbations;
Death is unusual.
Horse sickness fever
this is an executive agency working on behalf of Defra, Scottish Government and Welsh Government;
single agency response for animal, plant and bee health;
purpose is to identify, manage and eradicate outbreaks of exotic animal, plant and bee diseases and pests
Animal & Plant Health Agency (APHA)
name the 3 organisations that control notifiable diseases
- WOAH (World Organisation for ANimal Health)
- European Union
- UK Government (APHA)
what 2 things must any person having in his possession/under his charge an animal affected with a notifiable disease do?
- isolate the animal
- report to police force / APHA
these are diseases that are of:
- significant economic, trade and/or food security importance
- easily spread
- control requires cooperation from several countries
transboundary animal diseases (TADs)
name the 4 criteria for the inclusion of a disease in the WOAH list of transboundary animal diseases
- international spread of the pathogenic agent proven
- at least 1 country has demonstrated freedom from disease
- reliable means of detection & diagnosis exist
- natural transmission to humans has been proven OR disease has significant impact on health of domestic or wild animals
name the type of disease
legal obligation to notify the SUSPICION of a notifiable disease to APHA asap;
exotic or endemic;
controlled with legal powers
Notifiable Disease (ND)
name the type of disease
diseases communicated to APHA on POSITIVE ANALYSIS DETECTION asap/monthly
reportable disease
name the notifiable disease
RNA Aphtovirus, family Picornaviridae;
seven different serotypes;
no cross immunity;
stable at low temp and medium pH;
100% morbidity in naive cattle;
all cloven-hoofed animals affected;
does NOT affect humans;
mainly characterised by VESICLES
foot and mouth disease (FMD)
where does the 1st replication of FMD virus take place
pharyngeal and tonsillar region
where does the 2nd replication of FMD virus take place (3 places)
epithelium, mucosa, and myocardium
what is the incubation period of FMD?
2-14d
this species excretes large amounts of the virus causing FMD
(PRODUCE)
pigs
this species shows clinical signs of FMD
(INDICATE)
cattle
this species are generally asymptomatic when infected with FMD
(MAINTAIN)
sheep
name 5 initial clinical signs of FMD in cattle
- fever
- depression
- loss of appetite
- marked drop in milk yield
- salivation
name 5 complications that ocur as a result of FMD in cattle
- erosions (rupture of vesicles)
- infection of lesions
- myocarditis
- starvation
- abortion
what is the ideal sample to send to the National Reference Laboratory for FMD for diagnosis?
epithelium or vesicular fluid
name the 4 parts of the stamping out policy for FMD in infected premises
- susceptible animals humanely killed
- carcases disposed (hierarchy for disposal)
- C&D (prelim by APHA, secondary by farmer before restocking)
- compensation for animals culled
what type of vaccine is available for FMD
inactivated
where can FMD vaccination be used?
in areas where disease is endemic
(preventative use banned in UK)
name the transboundary notifiable animal disease
Morbillivirus;
fragile, inactivated w/in 12h;
led to creation in 1924 of the WOAH;
last GB outbreak in 1877;
first animal disease globally eradicated;
cloven-hoofed animals: mostly cattle
Rinderpest - cattle plague
name 4 clinical signs of Rinderpest
- sores in mouth/foul breath
- discharge from eyes, nose & mouth
- fever & dehydration
- diarrhoea or dysentery
name 3 samples to send to the National Reference Lab for diagnosis of Rinderpest
- serum
- swabs of lacrimal fluid
- tissues from oral lesions
what type of vaccine exists against Rinderpest
attenuated cell culture
name the transboundary notifiable animal disease
goat plague;
Morbillivirus, family Paramyxoviridae;
closely related to Rinderpest virus;
sheep & goats, wild small ruminants;
cattle, buffalo and pigs are dead-end hosts and do not show clinical signs
Peste des Petits Ruminants (PPR)
has Peste des Petits Ruminants (PPR) ever been reported in GB?
no